| Expectancy for food or expectancy for chocolate reveals timing systems for metabolism and reward. | |
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MedLine Citation:
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PMID: 18585440 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The clock gene protein Per 1 (PER1) is expressed in several brain structures and oscillates associated with the suprachiasmatic nucleus (SCN). Restricted feeding schedules (RFS) induce anticipatory activity and impose daily oscillations of c-Fos and clock proteins in brain structures. Daily access to a palatable treat (chocolate) also elicits anticipatory activity and induces c-Fos expression mainly in corticolimbic structures. Here the influence of daily access to food or chocolate was explored by the analysis of the oscillatory patterns of PER1 in hypothalamic and corticolimbic structures. Wistar rats were exposed to RFS or to daily access to chocolate for 3 weeks. Persistence of food or chocolate entrained rhythms was determined 8 days after cessation of the feeding protocols. RFS and chocolate induced a phase shift in PER1 rhythmicity in corticolimbic structures with peak values at zeitgeber time 12 and a higher amplitude in the chocolate group. Both RFS and chocolate groups showed an upregulation of PER1 in the SCN. Food and chocolate entrained rhythms persisted for 8 days in behavior and in PER1 expression in the dorsomedial hypothalamic nucleus, accumbens, prefrontal cortex and central amygdala. The present data demonstrate the existence of different oscillatory systems in the brain that can be activated by entrainment to metabolic stimuli or to reward and suggest the participation of PER1 in both entraining pathways. Persistence and amplification of PER1 oscillations in structures associated with reward suggest that this oscillatory process is fundamental to food addictive behavior. |
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Authors:
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M Angeles-Castellanos; R Salgado-Delgado; K Rodríguez; R M Buijs; C Escobar |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-06-07 |
Journal Detail:
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Title: Neuroscience Volume: 155 ISSN: 0306-4522 ISO Abbreviation: Neuroscience Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-07-23 Completed Date: 2008-11-05 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 7605074 Medline TA: Neuroscience Country: United States |
Other Details:
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Languages: eng Pagination: 297-307 Citation Subset: IM |
Affiliation:
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Departamento de Anatomía, Fac de Medicina Universidad Nacional Autónoma de México, México, Mexico. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Behavior, Animal Brain / anatomy & histology, metabolism* Cacao Cell Count Cell Cycle Proteins / metabolism* Circadian Rhythm / physiology* Feeding Behavior / physiology* Food Male Motivation* Motor Activity / physiology Period Circadian Proteins Rats Rats, Wistar Reward* |
| Chemical | |
Reg. No./Substance:
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0/Cell Cycle Proteins; 0/Per1 protein, rat; 0/Period Circadian Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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