Document Detail


Expectancy for food or expectancy for chocolate reveals timing systems for metabolism and reward.
MedLine Citation:
PMID:  18585440     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The clock gene protein Per 1 (PER1) is expressed in several brain structures and oscillates associated with the suprachiasmatic nucleus (SCN). Restricted feeding schedules (RFS) induce anticipatory activity and impose daily oscillations of c-Fos and clock proteins in brain structures. Daily access to a palatable treat (chocolate) also elicits anticipatory activity and induces c-Fos expression mainly in corticolimbic structures. Here the influence of daily access to food or chocolate was explored by the analysis of the oscillatory patterns of PER1 in hypothalamic and corticolimbic structures. Wistar rats were exposed to RFS or to daily access to chocolate for 3 weeks. Persistence of food or chocolate entrained rhythms was determined 8 days after cessation of the feeding protocols. RFS and chocolate induced a phase shift in PER1 rhythmicity in corticolimbic structures with peak values at zeitgeber time 12 and a higher amplitude in the chocolate group. Both RFS and chocolate groups showed an upregulation of PER1 in the SCN. Food and chocolate entrained rhythms persisted for 8 days in behavior and in PER1 expression in the dorsomedial hypothalamic nucleus, accumbens, prefrontal cortex and central amygdala. The present data demonstrate the existence of different oscillatory systems in the brain that can be activated by entrainment to metabolic stimuli or to reward and suggest the participation of PER1 in both entraining pathways. Persistence and amplification of PER1 oscillations in structures associated with reward suggest that this oscillatory process is fundamental to food addictive behavior.
Authors:
M Angeles-Castellanos; R Salgado-Delgado; K Rodríguez; R M Buijs; C Escobar
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-06-07
Journal Detail:
Title:  Neuroscience     Volume:  155     ISSN:  0306-4522     ISO Abbreviation:  Neuroscience     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-07-23     Completed Date:  2008-11-05     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  7605074     Medline TA:  Neuroscience     Country:  United States    
Other Details:
Languages:  eng     Pagination:  297-307     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Behavior, Animal
Brain / anatomy & histology,  metabolism*
Cacao
Cell Count
Cell Cycle Proteins / metabolism*
Circadian Rhythm / physiology*
Feeding Behavior / physiology*
Food
Male
Motivation*
Motor Activity / physiology
Period Circadian Proteins
Rats
Rats, Wistar
Reward*
Chemical
Reg. No./Substance:
0/Cell Cycle Proteins; 0/Per1 protein, rat; 0/Period Circadian Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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