| Expansion of signal transduction networks. | |
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MedLine Citation:
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PMID: 16986318 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Signal transduction networks of different cell types show a large variety in their structural design. In this paper, basic structural properties of signal transduction networks are investigated. For this, such networks with the recently developed method of network expansion are analysed. This method allows for a structural analysis of networks by calculating signal expansion profiles when provided with certain compounds, for example growth factors, inactive kinases and so on (seed compounds), to initiate such an expansion. The presented results may put forth valuable hints on the evolution of signalling networks. |
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Authors:
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B Binder; O Ebenhöh; K Hashimoto; R Heinrich |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Systems biology Volume: 153 ISSN: 1741-2471 ISO Abbreviation: Syst Biol (Stevenage) Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2006-09-21 Completed Date: 2006-10-30 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 101232067 Medline TA: Syst Biol (Stevenage) Country: England |
Other Details:
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Languages: eng Pagination: 364-8 Citation Subset: IM |
Affiliation:
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Theoretical Biophysics, Institute of Biology, Humboldt University Berlin, Invalidenstrasse 42, Berlin D-10115, Germany. bernd.binder@rz.hu-berlin.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms* Animals Cell Physiological Phenomena* Computer Simulation Humans Kinetics Models, Biological* Proteome / metabolism* Signal Transduction / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Proteome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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