Document Detail

Expansion of signal transduction networks.
MedLine Citation:
PMID:  16986318     Owner:  NLM     Status:  MEDLINE    
Signal transduction networks of different cell types show a large variety in their structural design. In this paper, basic structural properties of signal transduction networks are investigated. For this, such networks with the recently developed method of network expansion are analysed. This method allows for a structural analysis of networks by calculating signal expansion profiles when provided with certain compounds, for example growth factors, inactive kinases and so on (seed compounds), to initiate such an expansion. The presented results may put forth valuable hints on the evolution of signalling networks.
B Binder; O Ebenhöh; K Hashimoto; R Heinrich
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Systems biology     Volume:  153     ISSN:  1741-2471     ISO Abbreviation:  Syst Biol (Stevenage)     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-09-21     Completed Date:  2006-10-30     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  101232067     Medline TA:  Syst Biol (Stevenage)     Country:  England    
Other Details:
Languages:  eng     Pagination:  364-8     Citation Subset:  IM    
Theoretical Biophysics, Institute of Biology, Humboldt University Berlin, Invalidenstrasse 42, Berlin D-10115, Germany.
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MeSH Terms
Cell Physiological Phenomena*
Computer Simulation
Models, Biological*
Proteome / metabolism*
Signal Transduction / physiology*
Reg. No./Substance:

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