Document Detail

Expansion of indications for endoscopic treatment of undifferentiated mucosal gastric cancer: analysis of intramucosal spread in resected specimens.
MedLine Citation:
PMID:  19657738     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The aim of this study was to pathologically investigate the developmental pattern of undifferentiated mucosal gastric cancer and to determine safe surgical margins for curative resection by endoscopic resection. RESULTS: Intramucosal cancer spread, or the width of the proliferative zone, was pathologically investigated in 47 cases of undifferentiated mucosal gastric cancer of size 20 mm or smaller without ulceration (scars). The 47 cases comprised 40 IIc and 7 IIb cases. The IIc cases consisted of 5 (12.5%) of intermediate-layer type (cancer localized at the intermediate layer of the mucosa), 31 (77.5%) of superficial type, and 4 of whole-layer type (10%). The IIb cases consisted of six of intermediate-layer type (85.7%) and one of superficial type (14.3%). The width of the proliferative zone in the 40 IIc cases ranged from 0 to 2,390 microm (average 605.5 microm). There was no significant correlation between width of proliferative zone and background mucosa. With regard to lesion size, average width was 243.6 microm in cases with longest diameter <or=5 mm, while it was significantly larger (617.1 microm) in cases with diameter >5 mm. CONCLUSIONS: In endoscopic treatment of undifferentiated mucosal gastric cancer of size 20 mm or smaller without ulceration (scars), the lateral safety margin should be 3 mm or more.
Susumu Sawada; Junko Fujisaki; Noriko Yamamoto; You Kato; Akiyoshi Ishiyama; Nobue Ueki; Toshiaki Hirasawa; Yorimasa Yamamoto; Tomohiro Tsuchida; Makoto Tatewaki; Etsuo Hoshino; Masahiro Igarashi; Hiroshi Takahashi; Rikiya Fujita
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Publication Detail:
Type:  Journal Article     Date:  2009-08-06
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  55     ISSN:  1573-2568     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-04     Completed Date:  2010-06-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1376-80     Citation Subset:  AIM; IM    
Department of Gastroenterology, Showa University Fujigaoka Hospital, Tokyo, Japan.
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MeSH Terms
Gastric Mucosa / pathology*,  surgery*
Lymph Node Excision
Neoplasm Invasiveness
Stomach Neoplasms / pathology*,  surgery*
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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