Document Detail

Expanding perfusion services through mobile point-of-care coagulation monitoring.
MedLine Citation:
PMID:  12395965     Owner:  NLM     Status:  MEDLINE    
Current trends in cardiac surgery have challenged perfusionists to seek diversification of services. Point-of-care coagulation (POCC) monitoring represents a desirable area of perfusion service expansion. The purpose of the study was to create a series of hemostatic conditions to assess the functionality of POCC monitors to identify specific coagulopathies with identifiable profiles for algorithm development. Fresh (< 4 h) bovine blood, anticoagulated with anticoagulant citrate dextrose, was adjusted to a hematocrit of 30.0 +/- 2.0%. Hypofibrinogenemia < or = 90 mg/dL), thrombocytopenia (< or = 70,000/mm3), platelet dysfunction (850 microg/mL of nitroglycerin/mL of blood) and hyperfibrinolysis (0.40 units of urokinase/mL of blood) were created. Five POCC devices were used to evaluate activated clotting time, thrombin time, fibrinogen, platelet function, prothrombin time, activated partial thromboplastin time and thromboelastograph. Results are reported as percentage change from control for each test (abtract table). [table: see text] Each test performed showed specificity and sensitivity for certain coagulopathies, however variability amongst monitors was encountered. In conclusion, the development of a mobile cart incorporating POCC monitors with knowledge of specific coagulopathic conditions may expand perfusion service.
Ryan J Kohtz; Alfred H Stammers; Nancy J Mills; Craig M Petterson; Jeffery D Nichols; Scott A Kmiecik; Jun-Li Liu; Hong Zheng
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of extra-corporeal technology     Volume:  34     ISSN:  0022-1058     ISO Abbreviation:  J Extra Corpor Technol     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-10-24     Completed Date:  2002-11-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0267637     Medline TA:  J Extra Corpor Technol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  190-6     Citation Subset:  T    
Division of Clinical Perfusion Education, University of Nebraska Medical Center, School of Allied Health Professions, Omaha 68198-5155, USA.
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MeSH Terms
Blood Coagulation Disorders / diagnosis
Blood Coagulation Tests / methods*
Hong Kong
Monitoring, Physiologic / methods*
Point-of-Care Systems*
Sensitivity and Specificity
Thoracic Surgery*

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