Document Detail

Expanding the opportunities for blocking the renin-angiotensin system: introduction to a special supplement.
MedLine Citation:
PMID:  17401311     Owner:  NLM     Status:  MEDLINE    
The previous dogma that the renin-angiotensin system exerts its effects entirely through angiotensin II is now under challenge as scientists explore the properties of the prorenin/renin receptor and start to study local vascular actions of renin independent of its production of angiotensin in the plasma. The demonstrated blood pressure effects of the first clinically developed renin inhibitor, aliskiren, have confirmed the validity of this new class of drugs. Future research, exploring effects on the renin-angiotensin system that perhaps cannot be provided by the currently used blockers of this system, will test whether enhanced clinical benefits might result from this new pharmacologic strategy in patients at risk of cardiovascular events.
Michael A Weber
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Reviews in cardiovascular medicine     Volume:  8 Suppl 2     ISSN:  1530-6550     ISO Abbreviation:  Rev Cardiovasc Med     Publication Date:  2007  
Date Detail:
Created Date:  2007-04-02     Completed Date:  2007-10-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100960007     Medline TA:  Rev Cardiovasc Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S1-6     Citation Subset:  IM    
State University of New York Downstate Medical Center, Brooklyn, NY, USA.
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MeSH Terms
Amides / therapeutic use*
Fumarates / therapeutic use*
Heart Failure / blood,  drug therapy*
Hypertension / blood,  drug therapy*
Renin / antagonists & inhibitors*,  blood
Renin-Angiotensin System / drug effects*
Treatment Outcome
Reg. No./Substance:
0/Amides; 0/Fumarates; 0/aliskiren; EC

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