| Expanding the opportunities for blocking the renin-angiotensin system: introduction to a special supplement. | |
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MedLine Citation:
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PMID: 17401311 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The previous dogma that the renin-angiotensin system exerts its effects entirely through angiotensin II is now under challenge as scientists explore the properties of the prorenin/renin receptor and start to study local vascular actions of renin independent of its production of angiotensin in the plasma. The demonstrated blood pressure effects of the first clinically developed renin inhibitor, aliskiren, have confirmed the validity of this new class of drugs. Future research, exploring effects on the renin-angiotensin system that perhaps cannot be provided by the currently used blockers of this system, will test whether enhanced clinical benefits might result from this new pharmacologic strategy in patients at risk of cardiovascular events. |
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Authors:
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Michael A Weber |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Reviews in cardiovascular medicine Volume: 8 Suppl 2 ISSN: 1530-6550 ISO Abbreviation: Rev Cardiovasc Med Publication Date: 2007 |
Date Detail:
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Created Date: 2007-04-02 Completed Date: 2007-10-04 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100960007 Medline TA: Rev Cardiovasc Med Country: United States |
Other Details:
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Languages: eng Pagination: S1-6 Citation Subset: IM |
Affiliation:
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State University of New York Downstate Medical Center, Brooklyn, NY, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amides
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therapeutic use* Fumarates / therapeutic use* Heart Failure / blood, drug therapy* Humans Hypertension / blood, drug therapy* Renin / antagonists & inhibitors*, blood Renin-Angiotensin System / drug effects* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Amides; 0/Fumarates; 0/aliskiren; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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