Document Detail

Expanding nucleic acid function in vitro and in vivo.
MedLine Citation:
PMID:  17055771     Owner:  NLM     Status:  MEDLINE    
Nucleic Acids composed of the five natural bases and a phosphate backbone can be designed or evolved to have a wide variety of sequence-dependent functions. Recent in vitro work has addressed some outstanding issues in evolving nucleic acid catalysts, as well as the creation of prescribed shapes and arrays from oligonucleotides and long single-stranded nucleic acids. Nucleic acids have also been engineered in vivo, leading to new modes of gene regulation. It is likely that the improving ability to synthesize long DNA sequences will accelerate the creation of novel functions from nucleic acids.
T Ashton Cropp; Jason W Chin
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2006-10-19
Journal Detail:
Title:  Current opinion in chemical biology     Volume:  10     ISSN:  1367-5931     ISO Abbreviation:  Curr Opin Chem Biol     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-12-04     Completed Date:  2007-02-13     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  9811312     Medline TA:  Curr Opin Chem Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  601-6     Citation Subset:  IM    
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MeSH Terms
Nucleic Acids / metabolism,  physiology*
RNA Processing, Post-Transcriptional
RNA, Messenger / genetics
Grant Support
MC_U105181009//Medical Research Council
Reg. No./Substance:
0/Nucleic Acids; 0/RNA, Messenger

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