| Expanding nucleic acid function in vitro and in vivo. | |
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MedLine Citation:
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PMID: 17055771 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nucleic Acids composed of the five natural bases and a phosphate backbone can be designed or evolved to have a wide variety of sequence-dependent functions. Recent in vitro work has addressed some outstanding issues in evolving nucleic acid catalysts, as well as the creation of prescribed shapes and arrays from oligonucleotides and long single-stranded nucleic acids. Nucleic acids have also been engineered in vivo, leading to new modes of gene regulation. It is likely that the improving ability to synthesize long DNA sequences will accelerate the creation of novel functions from nucleic acids. |
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Authors:
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T Ashton Cropp; Jason W Chin |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2006-10-19 |
Journal Detail:
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Title: Current opinion in chemical biology Volume: 10 ISSN: 1367-5931 ISO Abbreviation: Curr Opin Chem Biol Publication Date: 2006 Dec |
Date Detail:
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Created Date: 2006-12-04 Completed Date: 2007-02-13 Revised Date: 2009-08-25 |
Medline Journal Info:
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Nlm Unique ID: 9811312 Medline TA: Curr Opin Chem Biol Country: England |
Other Details:
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Languages: eng Pagination: 601-6 Citation Subset: IM |
Affiliation:
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Department of Chemistry and Biochemistry, University of Maryland,College Park, MD, USA. acropp@umd.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Catalysis Nanotechnology Nucleic Acids / metabolism, physiology* RNA Processing, Post-Transcriptional RNA, Messenger / genetics |
| Chemical | |
Reg. No./Substance:
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0/Nucleic Acids; 0/RNA, Messenger |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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