Document Detail


Expanding the genetic code of Drosophila melanogaster.
MedLine Citation:
PMID:  22864544     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Genetic code expansion for unnatural amino acid mutagenesis has, until recently, been limited to cell culture. We demonstrate the site-specific incorporation of unnatural amino acids into proteins in Drosophila melanogaster at different developmental stages, in specific tissues and in a subset of cells within a tissue. This approach provides a foundation for probing and controlling processes in this established metazoan model organism with a new level of molecular precision.
Authors:
Ambra Bianco; Fiona M Townsley; Sebastian Greiss; Kathrin Lang; Jason W Chin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-08-05
Journal Detail:
Title:  Nature chemical biology     Volume:  8     ISSN:  1552-4469     ISO Abbreviation:  Nat. Chem. Biol.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-24     Completed Date:  2012-10-24     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  101231976     Medline TA:  Nat Chem Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  748-50     Citation Subset:  IM    
Data Bank Information
Bank Name/Acc. No.:
PubChem-Substance/136903170;  136903171;  136903172
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MeSH Terms
Descriptor/Qualifier:
Animals
Drosophila melanogaster / genetics*
Female
Genetic Code*
Grant Support
ID/Acronym/Agency:
MC_UP_A024_1008//Medical Research Council; U105181009//Medical Research Council; UD99999908//Medical Research Council

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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