| Expanding the chemical space in practice: diversity-oriented synthesis. | |
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MedLine Citation:
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PMID: 18795878 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Diversity-Oriented Synthesis (DOS) aims to broaden the frontier of accessible collections of complex and diverse small molecules. This review endeavours to dissect the DOS concept through three elements of diversity: building block, stereochemistry, and skeleton. Recent examples in the literature that emphasize the efficient combinations of these elements to generate diversity are reported. |
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Authors:
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Marine Peuchmaur; Yung-Sing Wong |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Combinatorial chemistry & high throughput screening Volume: 11 ISSN: 1386-2073 ISO Abbreviation: Comb. Chem. High Throughput Screen. Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-09-17 Completed Date: 2008-10-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9810948 Medline TA: Comb Chem High Throughput Screen Country: Netherlands |
Other Details:
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Languages: eng Pagination: 587-601 Citation Subset: IM |
Affiliation:
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Département de Pharmacochimie Moléculaire, Université de Grenoble/CNRS UMR 5063, CNRS ICMG FR 2607 Bâtiment E, Bâtiment André Rassat, 470 rue de la Chimie, Grenoble Cedex 9, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers*
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chemistry Combinatorial Chemistry Techniques* Drug Design Molecular Structure Signal Transduction Stereoisomerism |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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