Document Detail


Expanding the chemical space in practice: diversity-oriented synthesis.
MedLine Citation:
PMID:  18795878     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Diversity-Oriented Synthesis (DOS) aims to broaden the frontier of accessible collections of complex and diverse small molecules. This review endeavours to dissect the DOS concept through three elements of diversity: building block, stereochemistry, and skeleton. Recent examples in the literature that emphasize the efficient combinations of these elements to generate diversity are reported.
Authors:
Marine Peuchmaur; Yung-Sing Wong
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Combinatorial chemistry & high throughput screening     Volume:  11     ISSN:  1386-2073     ISO Abbreviation:  Comb. Chem. High Throughput Screen.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-09-17     Completed Date:  2008-10-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9810948     Medline TA:  Comb Chem High Throughput Screen     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  587-601     Citation Subset:  IM    
Affiliation:
Département de Pharmacochimie Moléculaire, Université de Grenoble/CNRS UMR 5063, CNRS ICMG FR 2607 Bâtiment E, Bâtiment André Rassat, 470 rue de la Chimie, Grenoble Cedex 9, France.
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MeSH Terms
Descriptor/Qualifier:
Biological Markers* / chemistry
Combinatorial Chemistry Techniques*
Drug Design
Molecular Structure
Signal Transduction
Stereoisomerism
Chemical
Reg. No./Substance:
0/Biological Markers

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