| Expanding chemical biology of 2-oxoglutarate oxygenases. | |
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MedLine Citation:
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PMID: 18277970 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Beyond established roles in collagen biosynthesis, hypoxic signaling and fatty acid metabolism, recent reports have now revealed roles for human 2-oxoglutarate-dependent oxygenases in histone and nucleic acid demethylation and in signaling protein hydroxylation. The emerging role of these oxygenases in enabling a multiplicity of histone modifications has some analogy with their role in enabling structural diversity in secondary metabolism. |
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Authors:
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Christoph Loenarz; Christopher J Schofield |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Nature chemical biology Volume: 4 ISSN: 1552-4469 ISO Abbreviation: Nat. Chem. Biol. Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-02-18 Completed Date: 2008-09-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101231976 Medline TA: Nat Chem Biol Country: United States |
Other Details:
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Languages: eng Pagination: 152-6 Citation Subset: IM |
Affiliation:
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Chemistry Research Laboratory and the Oxford Centre for Integrative Systems Biology, Mansfield Road, Oxford OX1 3TA, UK. christopher.schofield@chem.ox.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Catalysis Histones / chemistry, physiology Humans Hydroxylation Ketoglutaric Acids / metabolism* Methylation Models, Molecular Nucleic Acids / chemical synthesis, chemistry Oxidation-Reduction Oxygenases / chemistry*, physiology* Proteins / chemistry, physiology Signal Transduction / physiology Stereoisomerism |
| Grant Support | |
ID/Acronym/Agency:
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//Wellcome Trust |
| Chemical | |
Reg. No./Substance:
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0/Histones; 0/Ketoglutaric Acids; 0/Nucleic Acids; 0/Proteins; 328-50-7/alpha-ketoglutaric acid; EC 1.13.-/Oxygenases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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