Document Detail

Expanding cardiac resynchronization for systolic heart failure to patients with mechanical dyssynchrony and atrial fibrillation.
MedLine Citation:
PMID:  16195687     Owner:  NLM     Status:  MEDLINE    
Despite progress in the management of heart failure (HF) using pharmacotherapy, the mortality and morbidity associated with this condition remain unacceptably high. Cardiac resynchronization therapy (CRT), a left-sided pacing therapy for drug-refractory and highly symptomatic HF patients with ventricular conduction delay, has been shown to improve left ventricular (LV) systolic function, myocardial oxygen consumption, and New York Heart Association functional class and to inhibit or reverse LV chamber dilation and remodeling. Atrial fibrillation is common in patients with HF and is associated with significant worsening of HF and myocardial function. Only recently have trials been designed to specifically study CRT in patients with HF and chronic atrial fibrillation. These studies have shown that CRT with biventricular or univentricular LV pacing in patients with atrial fibrillation corrects mechanical dyssynchrony and results in significant and sustained improvement in functional capacity, LV ejection fraction, quality of life, and QRS duration.
Hamid Ghanbari; Bischan Hassunizadeh; Christian Machado
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Reviews in cardiovascular medicine     Volume:  6     ISSN:  1530-6550     ISO Abbreviation:  Rev Cardiovasc Med     Publication Date:  2005  
Date Detail:
Created Date:  2005-09-30     Completed Date:  2005-12-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100960007     Medline TA:  Rev Cardiovasc Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  140-51     Citation Subset:  IM    
Cardiology Division, Providence Hospital and Medical Centers, Southfield, Michigan, USA.
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MeSH Terms
Atrial Fibrillation / complications*,  mortality,  therapy*
Cardiac Pacing, Artificial*
Electric Countershock*
Heart Failure / complications*,  mortality,  therapy*
Survival Rate
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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