Document Detail


The expanding bacterial type IV secretion lexicon.
MedLine Citation:
PMID:  23542405     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The bacterial type IV secretion systems (T4SSs) comprise a biologically diverse group of translocation systems functioning to deliver DNA or protein substrates from donor to target cells generally by a mechanism dependent on establishment of direct cell-to-cell contact. Members of one T4SS subfamily, the conjugation systems, mediate the widespread and rapid dissemination of antibiotic resistance and virulence traits among bacterial pathogens. Members of a second subfamily, the effector translocators, are used by often medically-important pathogens to deliver effector proteins to eukaryotic target cells during the course of infection. Here we summarize our current understanding of the structural and functional diversity of T4SSs and of the evolutionary processes shaping this diversity. We compare mechanistic and architectural features of T4SSs from Gram-negative and -positive species. Finally, we introduce the concept of the 'minimized' T4SSs; these are systems composed of a conserved set of 5-6 subunits that are distributed among many Gram-positive and some Gram-negative species.
Authors:
Minny Bhatty; Jenny A Laverde Gomez; Peter J Christie
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2013-03-28
Journal Detail:
Title:  Research in microbiology     Volume:  164     ISSN:  1769-7123     ISO Abbreviation:  Res. Microbiol.     Publication Date:    2013 Jul-Aug
Date Detail:
Created Date:  2013-07-08     Completed Date:  2014-01-27     Revised Date:  2014-07-02    
Medline Journal Info:
Nlm Unique ID:  8907468     Medline TA:  Res Microbiol     Country:  France    
Other Details:
Languages:  eng     Pagination:  620-39     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Bacteria / chemistry,  classification,  genetics,  metabolism*
Bacterial Infections / microbiology
Bacterial Proteins / chemistry,  genetics,  metabolism*
Bacterial Secretion Systems*
Humans
Phylogeny
Protein Transport
Grant Support
ID/Acronym/Agency:
R01 GM048746/GM/NIGMS NIH HHS; R01GM48746/GM/NIGMS NIH HHS; R21 AI105454/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Bacterial Proteins
Comments/Corrections

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