Document Detail


Expanded clinical evaluation of lovastatin (EXCEL) study results. II. Assessment of the human lens after 48 weeks of treatment with lovastatin.
MedLine Citation:
PMID:  1998274     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The crystalline lenses of hypercholesterolemic patients were assessed before and after 48 weeks of treatment with lovastatin or placebo to determine the effect of lovastatin on the human lens. Patients were given a biomicroscopic (slit-lamp) examination of the lens, and a previously validated, standardized classification system was used to describe the findings. A total of 8,245 patients were randomly assigned in equal numbers to treatment with placebo or lovastatin 20 or 40 mg once or twice daily in this double-blind, parallel-group study. Statistical analyses of the distribution of cortical, nuclear and subcapsular opacities at 48 weeks, adjusted for age and presence of an opacity at baseline, showed no significant differences (p less than 0.01) between the placebo and lovastatin-treated groups. Visual acuity assessments at week 48 were also not found to have significantly different distributions among treatment groups. Moreover, no significant differences were found among the groups in the frequencies of greater than or equal to 2-line worsening in visual acuity with concurrent progression in lenticular opacity, cataract extraction, or any spontaneously reported adverse ophthalmologic experience. No evidence was found for an effect of lovastatin on the human lens after 48 weeks of treatment.
Authors:
A M Laties; C L Shear; E A Lippa; A L Gould; H R Taylor; D P Hurley; W P Stephenson; E U Keates; M A Tupy-Visich; A N Chremos
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of cardiology     Volume:  67     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1991 Mar 
Date Detail:
Created Date:  1991-04-01     Completed Date:  1991-04-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  447-53     Citation Subset:  AIM; IM    
Affiliation:
Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania School of Medicine, Philadelphia 19104.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Cataract / chemically induced
Double-Blind Method
Female
Humans
Hypercholesterolemia / drug therapy
Lens, Crystalline / drug effects*,  pathology
Lovastatin / adverse effects*,  therapeutic use
Male
Middle Aged
Visual Acuity / drug effects
Chemical
Reg. No./Substance:
75330-75-5/Lovastatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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