Document Detail

Exotoxins of Staphylococcus aureus.
MedLine Citation:
PMID:  10627489     Owner:  NLM     Status:  MEDLINE    
This article reviews the literature regarding the structure and function of two types of exotoxins expressed by Staphylococcus aureus, pyrogenic toxin superantigens (PTSAgs) and hemolysins. The molecular basis of PTSAg toxicity is presented in the context of two diseases known to be caused by these exotoxins: toxic shock syndrome and staphylococcal food poisoning. The family of staphylococcal PTSAgs presently includes toxic shock syndrome toxin-1 (TSST-1) and most of the staphylococcal enterotoxins (SEs) (SEA, SEB, SEC, SED, SEE, SEG, and SEH). As the name implies, the PTSAgs are multifunctional proteins that invariably exhibit lethal activity, pyrogenicity, superantigenicity, and the capacity to induce lethal hypersensitivity to endotoxin. Other properties exhibited by one or more staphylococcal PTSAgs include emetic activity (SEs) and penetration across mucosal barriers (TSST-1). A detailed review of the molecular mechanisms underlying the toxicity of the staphylococcal hemolysins is also presented.
M M Dinges; P M Orwin; P M Schlievert
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Clinical microbiology reviews     Volume:  13     ISSN:  0893-8512     ISO Abbreviation:  Clin. Microbiol. Rev.     Publication Date:  2000 Jan 
Date Detail:
Created Date:  2000-02-16     Completed Date:  2000-02-16     Revised Date:  2013-04-17    
Medline Journal Info:
Nlm Unique ID:  8807282     Medline TA:  Clin Microbiol Rev     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  16-34, table of contents     Citation Subset:  IM    
Department of Microbiology, University of Minnesota School of Medicine, Minneapolis, Minnesota 55455, USA.
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MeSH Terms
Exotoxins / chemistry*,  metabolism*
Hemolysin Proteins / chemistry,  metabolism
Leukocidins / chemistry,  metabolism
Staphylococcal Infections / microbiology*,  pathology,  physiopathology
Staphylococcus aureus / metabolism*
Grant Support
Reg. No./Substance:
0/Exotoxins; 0/Hemolysin Proteins; 0/Leukocidins

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