Document Detail


Exotoxins of Staphylococcus aureus.
MedLine Citation:
PMID:  10627489     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This article reviews the literature regarding the structure and function of two types of exotoxins expressed by Staphylococcus aureus, pyrogenic toxin superantigens (PTSAgs) and hemolysins. The molecular basis of PTSAg toxicity is presented in the context of two diseases known to be caused by these exotoxins: toxic shock syndrome and staphylococcal food poisoning. The family of staphylococcal PTSAgs presently includes toxic shock syndrome toxin-1 (TSST-1) and most of the staphylococcal enterotoxins (SEs) (SEA, SEB, SEC, SED, SEE, SEG, and SEH). As the name implies, the PTSAgs are multifunctional proteins that invariably exhibit lethal activity, pyrogenicity, superantigenicity, and the capacity to induce lethal hypersensitivity to endotoxin. Other properties exhibited by one or more staphylococcal PTSAgs include emetic activity (SEs) and penetration across mucosal barriers (TSST-1). A detailed review of the molecular mechanisms underlying the toxicity of the staphylococcal hemolysins is also presented.
Authors:
M M Dinges; P M Orwin; P M Schlievert
Related Documents :
11934569 - Incidence of toxic aeromonas isolated from food and human infection.
10484739 - Dynamics of microcystins in the mussel mytilus galloprovincialis.
12565739 - Spatial and temporal evolution of psp toxins along the atlantic shore of morocco.
4963439 - Resistance of bacillus subtilis var. niger spores occluded in water-insoluble crystals ...
16819899 - Development of a fluorescent latex microparticle immunoassay for the detection of staph...
8504869 - Diet/toxin interactions.
17133829 - Inactivation of protozoan parasites in food, water, and environmental systems.
6523129 - Health and environmental implications of trace metals released from coal-fired power pl...
17284889 - Physiological and subjective assessment of food grain handling workers in west godavari...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Clinical microbiology reviews     Volume:  13     ISSN:  0893-8512     ISO Abbreviation:  Clin. Microbiol. Rev.     Publication Date:  2000 Jan 
Date Detail:
Created Date:  2000-02-16     Completed Date:  2000-02-16     Revised Date:  2013-04-17    
Medline Journal Info:
Nlm Unique ID:  8807282     Medline TA:  Clin Microbiol Rev     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  16-34, table of contents     Citation Subset:  IM    
Affiliation:
Department of Microbiology, University of Minnesota School of Medicine, Minneapolis, Minnesota 55455, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Exotoxins / chemistry*,  metabolism*
Hemolysin Proteins / chemistry,  metabolism
Humans
Leukocidins / chemistry,  metabolism
Staphylococcal Infections / microbiology*,  pathology,  physiopathology
Staphylococcus aureus / metabolism*
Grant Support
ID/Acronym/Agency:
AI 07421/AI/NIAID NIH HHS; AI22159/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Exotoxins; 0/Hemolysin Proteins; 0/Leukocidins
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Respiratory syncytial virus genetic and antigenic diversity.
Next Document:  Immune response to Giardia duodenalis.