Document Detail


Exosomes and communication between tumours and the immune system: are all exosomes equal?
MedLine Citation:
PMID:  23356294     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Communication between cells is particularly important during tumour progression. Communication can take place through direct cell-cell interactions, but also through extracellular secretion of mediators acting at a distance. These mediators can be either soluble molecules or more complex structures called membrane vesicles, enclosing soluble factors within a lipid bilayer. A variety of extracellular membrane vesicles have been described, for instance microvesicles, ectosomes and a subtype called exosomes. The role of exosomes in tumour progression has been studied extensively in the last 10 years. In the present mini-review, we discuss our recent results, first showing the heterogeneity of the vesicles called exosomes and the probable existence of subpopulations of these exosomes, and secondly demonstrating that in vivo secretion of exosomes by some tumours can promote tumour progression, but that such a function cannot be generalized to all tumours and all exosomes.
Authors:
Angélique Bobrie; Clotilde Théry
Related Documents :
12972644 - Mitochondrial positioning in fission yeast is driven by association with dynamic microt...
3317114 - Localization of an epitope of a microtubule-associated protein 1x in outgrowing axons o...
7624294 - Ultrastructure of spermiogenesis and spermatozoa of neopolystoma spratti (platyhelminth...
2582264 - Translocation of vesicles from squid axoplasm on flagellar microtubules.
7552354 - Monocular deprivation alters the morphology of glial fibrillary acidic protein-immunore...
2656094 - The evolution of pretransfusion testing: from agglutination to solid-phase red cell adh...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biochemical Society transactions     Volume:  41     ISSN:  1470-8752     ISO Abbreviation:  Biochem. Soc. Trans.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7506897     Medline TA:  Biochem Soc Trans     Country:  England    
Other Details:
Languages:  eng     Pagination:  263-7     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Interplay of host-pathogen microvesicles and their role in infectious disease.
Next Document:  Interactions of human monocytes with TMVs (tumour-derived microvesicles).