Document Detail

Exosomes as nucleic acid nanocarriers.
MedLine Citation:
PMID:  22750807     Owner:  NLM     Status:  Publisher    
Exosomes are nano-sized vesicles produced naturally by many cell types. They are specifically loaded with nucleic acid cargo, dependent on the exosome-producing cell and its homeostatic state. As natural intercellular shuttles of miRNA, exosomes influence an array of developmental, physiological and pathological processes in the recipient cell or tissue to which they can be selectively targeted by their tetraspanin surface-domains. By a review of current research, we here illustrate why exosomes are ideal nanocarriers for use in the targeted in vivo delivery of nucleic acids.
Jasper G van den Boorn; Juliane Daßler; Christoph Coch; Martin Schlee; Gunther Hartmann
Related Documents :
3801387 - The effects of intraruminal infusions of urea, casein, glucose syrup and a mixture of c...
12596847 - Induced volatiles in elicitor-treated and rice blast fungus-inoculated rice leaves.
9313157 - Effect of starch on the bioavailability of glutamine and leucine in the dairy cow.
6735467 - Role of volatile fatty acids in colonization resistance to clostridium difficile.
6086307 - Effect of mercuric chloride on some biochemical and physiological parameters of the fre...
668117 - Glucuronides of unconjugated 6-hydroxylated bile acids in urine of a patient with malab...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-27
Journal Detail:
Title:  Advanced drug delivery reviews     Volume:  -     ISSN:  1872-8294     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-7-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8710523     Medline TA:  Adv Drug Deliv Rev     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier B.V.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Finite and infinite dosing: Difficulties in measurements, evaluations and predictions.
Next Document:  First crystal structure of an endo-inulinase, INU2, from Aspergillus ficuum: discovery of an extra-p...