Document Detail


Exosomes as nucleic acid nanocarriers.
MedLine Citation:
PMID:  22750807     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Exosomes are nano-sized vesicles produced naturally by many cell types. They are specifically loaded with nucleic acid cargo, dependent on the exosome-producing cell and its homeostatic state. As natural intercellular shuttles of miRNA, exosomes influence an array of developmental, physiological and pathological processes in the recipient cell or tissue to which they can be selectively targeted by their tetraspanin surface-domains. By a review of current research, we here illustrate why exosomes are ideal nanocarriers for use in the targeted in vivo delivery of nucleic acids.
Authors:
Jasper G van den Boorn; Juliane Daßler; Christoph Coch; Martin Schlee; Gunther Hartmann
Related Documents :
22891977 - Crown-complexation of protonated amino acids: influence on irmpd spectra.
15545367 - Volatile free fatty acids as ripening indicators for serra da estrela cheese.
22315197 - The omega-6 fatty acid linoleic acid is associated with risk of gastroschisis: a novel ...
8572917 - Influence of avotan on the microflora and concentrations of ammonia and volatile fatty ...
18349237 - Dietary unsaturated fatty acids increase plasma glucagon-like peptide-1 and cholecystok...
10364307 - Isolation and characterization of a hantavirus from lemmus sibiricus: evidence for host...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-27
Journal Detail:
Title:  Advanced drug delivery reviews     Volume:  -     ISSN:  1872-8294     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-7-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8710523     Medline TA:  Adv Drug Deliv Rev     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier B.V.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Finite and infinite dosing: Difficulties in measurements, evaluations and predictions.
Next Document:  First crystal structure of an endo-inulinase, INU2, from Aspergillus ficuum: discovery of an extra-p...