Document Detail


Exosome: from internal vesicle of the multivesicular body to intercellular signaling device.
MedLine Citation:
PMID:  10984428     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Exosomes are small membrane vesicles that are secreted by a multitude of cell types as a consequence of fusion of multivesicular late endosomes/lysosomes with the plasma membrane. Depending on their origin, exosomes can play roles in different physiological processes. Maturing reticulocytes externalize obsolete membrane proteins such as the transferrin receptor by means of exosomes, whereas activated platelets release exosomes whose function is not yet known. Exosomes are also secreted by cytotoxic T cells, and these might ensure specific and efficient targeting of cytolytic substances to target cells. Antigen presenting cells, such as B lymphocytes and dendritic cells, secrete MHC class-I- and class-II-carrying exosomes that stimulate T cell proliferation in vitro. In addition, dendritic-cell-derived exosomes, when used as a cell-free vaccine, can eradicate established murine tumors. Although the precise physiological target(s) and functions of exosomes remain largely to be resolved, follicular dendritic cells (accessory cells in the germinal centers of secondary lymphoid organs) have recently been shown to bind B-lymphocyte-derived exosomes at their cell surface, which supports the notion that exosomes play an immunoregulatory role. Finally, since exosomes are derived from multivesicular bodies, their molecular composition might provide clues to the mechanism of protein and lipid sorting in endosomes.
Authors:
K Denzer; M J Kleijmeer; H F Heijnen; W Stoorvogel; H J Geuze
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of cell science     Volume:  113 Pt 19     ISSN:  0021-9533     ISO Abbreviation:  J. Cell. Sci.     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2000-11-15     Completed Date:  2000-11-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0052457     Medline TA:  J Cell Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  3365-74     Citation Subset:  IM    
Affiliation:
Department of Cell Biology, Institute of Biomembranes and Centre for Biomedical Genetics, University Medical Center Utrecht, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antigen-Presenting Cells / metabolism
Biological Transport*
Blood Platelets / metabolism,  ultrastructure
CD8-Positive T-Lymphocytes / metabolism,  secretion
Dendritic Cells, Follicular / metabolism,  ultrastructure
Endosomes / metabolism*
Humans
Lysosomes / metabolism
Major Histocompatibility Complex
Platelet Activation
Protein Transport
Reticulocytes / metabolism
Signal Transduction*
Transport Vesicles / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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