Document Detail


Exon 5 mutations in the p53 gene in relapsed childhood acute lymphoblastic leukemia.
MedLine Citation:
PMID:  9379679     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Thirty seven children with relapsed acute lymphoblastic leukemia (ALL), 25 B-lineage and 12 T-lineage, were analyzed for p53 alterations at different stages of the disease. Loss of heterozygosity (LOH) was detected in the relapse phase in three patients. p53 mutations were identified by single strand conformation polymorphism (SSCP) and sequencing analyzes in seven of the 37 ALL patients (19%); three B-lineage (12%) and four T-lineage (33%). Most of the mutations were identified in the relapse phase. In two exceptional cases, one of the mutations was indicated as a germ line and the other was already present at diagnosis. No p53 mutation was identified in any of the other 20 available bone marrow samples obtained at diagnosis. No correlation between the p53 status and clinical outcome could be determined. The majority of the mutations (four out of seven, 57%) were clustered at exon 5. Our data implicate that p53 exon 5 is a frequent site of mutations in relapsed childhood ALL.
Authors:
O Blau; S Avigad; B Stark; Y Kodman; D Luria; I J Cohen; R Zaizov
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Leukemia research     Volume:  21     ISSN:  0145-2126     ISO Abbreviation:  Leuk. Res.     Publication Date:  1997 Aug 
Date Detail:
Created Date:  1997-11-12     Completed Date:  1997-11-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7706787     Medline TA:  Leuk Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  721-9     Citation Subset:  IM    
Affiliation:
Felsenstein Medical Research Center, Department of Pediatric Hematology Oncology, Schneider Children's Medical Center of Israel, Israel.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Child
Child, Preschool
Disease Progression
Exons
Female
Genes, p53*
Humans
Loss of Heterozygosity
Male
Mutation*
Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
Recurrence
Sequence Analysis, DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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