Document Detail

Exon 5 mutations in the p53 gene in relapsed childhood acute lymphoblastic leukemia.
MedLine Citation:
PMID:  9379679     Owner:  NLM     Status:  MEDLINE    
Thirty seven children with relapsed acute lymphoblastic leukemia (ALL), 25 B-lineage and 12 T-lineage, were analyzed for p53 alterations at different stages of the disease. Loss of heterozygosity (LOH) was detected in the relapse phase in three patients. p53 mutations were identified by single strand conformation polymorphism (SSCP) and sequencing analyzes in seven of the 37 ALL patients (19%); three B-lineage (12%) and four T-lineage (33%). Most of the mutations were identified in the relapse phase. In two exceptional cases, one of the mutations was indicated as a germ line and the other was already present at diagnosis. No p53 mutation was identified in any of the other 20 available bone marrow samples obtained at diagnosis. No correlation between the p53 status and clinical outcome could be determined. The majority of the mutations (four out of seven, 57%) were clustered at exon 5. Our data implicate that p53 exon 5 is a frequent site of mutations in relapsed childhood ALL.
O Blau; S Avigad; B Stark; Y Kodman; D Luria; I J Cohen; R Zaizov
Related Documents :
19583749 - Genomic instability and tumor-specific dna alterations in oral leukoplakias.
19428789 - P53-mediated inhibition of angiogenesis in diffuse low-grade astrocytomas.
23197429 - A novel mutation in cdkn1c in sibs with beckwith-wiedemann syndrome and cleft palate, s...
16113669 - Genetic risk identifies multiple myeloma patients who do not benefit from autologous st...
9379679 - Exon 5 mutations in the p53 gene in relapsed childhood acute lymphoblastic leukemia.
12783209 - A possible role of the p53 gene deletion as a prognostic factor in multiple myeloma.
22839209 - Molecular epidemiology of drug resistance markers of plasmodium falciparum in yunnan pr...
24656159 - Efficient detection of factor ix mutations by denaturing high-performance liquid chroma...
9465419 - High-resolution dna fingerprinting of parthenogenetic root-knot nematodes using aflp an...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Leukemia research     Volume:  21     ISSN:  0145-2126     ISO Abbreviation:  Leuk. Res.     Publication Date:  1997 Aug 
Date Detail:
Created Date:  1997-11-12     Completed Date:  1997-11-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7706787     Medline TA:  Leuk Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  721-9     Citation Subset:  IM    
Felsenstein Medical Research Center, Department of Pediatric Hematology Oncology, Schneider Children's Medical Center of Israel, Israel.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Child, Preschool
Disease Progression
Genes, p53*
Loss of Heterozygosity
Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
Sequence Analysis, DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  NF-M trans-activates the human DNA topoisomerase II alpha promoter independently of c-Myb in HL-60 c...
Next Document:  Ca2+/Mg(2+)-dependent endonuclease in marrow CD34 positive and erythroid cells in myelodysplasia.