Document Detail

Exon-1 polymorphism of ctla-4 gene is not associated with systemic sclerosis in Iranian patients.
MedLine Citation:
PMID:  16189655     Owner:  NLM     Status:  MEDLINE    
Although, the cytotoxic T lymphocyte antigen-4 gene polymorphism at position 49 of exon-1 has been strongly elucidated in different autoimmune diseases, but its role in predisposition to systemic sclerosis (SSc) is yet controversial. This study intends to analyze the genetic correlation of the ctla-4 gene locus with diffuse systemic sclerosis (dSSc), as well as to understand the influence of these genotypes in disease expression. Seventy known cases of SSc, and 151 age-matched healthy controls, were participated in this investigation. The frequencies of AA, GG and AG genotypes were found to be 26 (37.1%), 5 (7.2%) and 39 (55.7%) in patients, and 60 (39.7%), 19 (12.6%) and 72 (47.7%) in controls, respectively. As indicated, the differences in genotype and allele frequencies between patients and controls were insignificant (P>0.05). Moreover, the distribution of CTLA-4 polymorphism between patients did not differ significantly according to clinical and serologic features. In Iranian patients, susceptibility to SSc is not influenced by a bi-allelic ctla-4 gene (A49G) polymorphism.
A Rajaee; A Ebrahimi; A Fotouhi Ghiam; T Kalantari; A Ghaderi
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-09-28
Journal Detail:
Title:  Rheumatology international     Volume:  26     ISSN:  0172-8172     ISO Abbreviation:  Rheumatol. Int.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-05-10     Completed Date:  2006-12-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8206885     Medline TA:  Rheumatol Int     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  687-92     Citation Subset:  IM    
Department of Rheumatology, Shiraz University of Medical Sciences, Shiraz, Iran.
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MeSH Terms
Age of Onset
Antigens, CD / genetics*
Antigens, Differentiation / genetics*
Case-Control Studies
Gene Frequency
Iran / epidemiology
Middle Aged
Polymorphism, Genetic*
Scleroderma, Systemic / genetics*,  pathology
Reg. No./Substance:
0/Antigens, CD; 0/Antigens, Differentiation; 0/cytotoxic T-lymphocyte antigen 4

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