| Exogenously administered opioids contract the female rat intrinsic urethral sphincter in vivo. | |
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MedLine Citation:
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PMID: 19899147 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND OBJECTIVE: Previous studies have reported immunoreactive opioid nerve fibers in the detrusor and lower urinary tract sphincters. However, there is a paucity of in vivo studies demonstrating the direct effect of endogenous opioids in these structures. In the present study, we investigated the contractile actions of intra-arterially administered exogenous Dynorphin-A, Met-enkephalin, Leu-enkephalin, morphine, and the opioid antagonist naltrexone on the female rat intrinsic urethral sphincter in vivo. METHODS: Intraurethral pressure was recorded by a catheter placed at the maximum pressure zone of the intrinsic urethral sphincter in anesthetized female Sprague-Dawley rats. The effects of different opioids were studied and expressed as means and as percentages of pressure change (cmH(2)O) of the baseline intraurethral pressure. RESULTS: Dynorphin-A, Met-enkephalin, and Leu-enkephalin evoked rapid, long-lasting contractile effects on the female rat urethra. The greatest intraurethral pressure increase was evoked by Dynorphin-A (89.2 +/- 15.3%). For Met-enkephalin, intraurethral pressure increased by 70.2 +/- 21.8% and for Leu-enkephalin, the pressure increase was 60.6 +/- 20%. Morphine, however, evoked inconsistent intraurethral pressure changes, increasing the urethral pressure in three subjects and lowering the pressure in the remaining six subjects. The opioid antagonist naltrexone reduced the intraurethral pressure by a mean of -19.0 +/- 5.8%. CONCLUSION: Results of the present study suggest that endogenous opioids by their contractile action on the intrinsic urethral sphincter may play a role in the control of continence in rats, additional to cholinergic and noradrenergic pathways. |
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Authors:
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Robert Crayton; Wolfgang Soller; Anders Mattiasson; Agnieszka Bossowska; Tomasz Borkowski; Mariusz Majewski; Piotr Radziszewski |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Neurourology and urodynamics Volume: 29 ISSN: 1520-6777 ISO Abbreviation: Neurourol. Urodyn. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-07-01 Completed Date: 2010-12-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8303326 Medline TA: Neurourol Urodyn Country: United States |
Other Details:
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Languages: eng Pagination: 777-82 Citation Subset: IM |
Copyright Information:
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(c) 2010 Wiley-Liss, Inc. |
Affiliation:
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Department of Clinical and Experimental Physiology, Medical University of Warsaw, Warsaw, Poland. rcrayton@wum.edu.pl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analgesics, Opioid
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pharmacology* Animals Female Muscle Contraction / drug effects* Rats Rats, Sprague-Dawley Urethra / drug effects*, physiology* |
| Chemical | |
Reg. No./Substance:
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0/Analgesics, Opioid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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