Document Detail

Exogenous vasopressin modulates activity of oxytocin neurons in homozygous Brattleboro rats.
MedLine Citation:
PMID:  3777164     Owner:  NLM     Status:  MEDLINE    
We studied the effects of chronic replacement with arginine vasopressin (AVP) or 1-desamino-D-arginine vasopressin (DDAVP), as well as acute replacement with AVP or DDAVP, on the responsiveness of oxytocin (OT) neurons as indexed by plasma oxytocin-associated neurophysin concentration [( OT-RNP]) during acute salt loading in conscious, chronically catheterized homozygous Brattleboro (DI) rats. Salt loading was carried out on days 5 and 12 of AVP (3,000 ng/day) or DDAVP (50 ng/day) treatment or 60 min after intraperitoneal injection of 1 microgram AVP or 25 ng DDAVP. All vasopressin treatments did not significantly alter the basal [OT-RNP]. In response to infusion of 18% saline, there were corresponding significant increases in plasma osmolality (Posmol) and [OT-RNP] in all animals. The increases in [OT-RNP] in vasopressin-treated DI rats were markedly reduced compared with those observed earlier for untreated DI animals despite similar rises in Posmol. The slopes of the relationship between delta [OT-RNP] and delta Posmol were 9.0 and 9.8 fmol X ml-1 X mosmol-1 X kg for chronically AVP-treated DI rats, 8.9, and 8.8 fmol X ml-1 X mosmol-1 X kg for chronically DDAVP-treated DI animals, 10.7 fmol X ml-1 X mosmol-1 X kg for acutely AVP-treated DI rats, and 8.3 fmol X ml-1 X mosmol-1 X kg for acutely DDAVP-treated animals compared with that of 34.9 fmol X ml-1 X mosmol-1 X kg for untreated DI rats.(ABSTRACT TRUNCATED AT 250 WORDS)
S W Cheng; W G North
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  251     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1986 Nov 
Date Detail:
Created Date:  1986-12-12     Completed Date:  1986-12-12     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  E556-62     Citation Subset:  IM    
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MeSH Terms
Deamino Arginine Vasopressin / pharmacology
Diabetes Insipidus / physiopathology*
Neurons / physiology*
Neurophysins / blood
Osmolar Concentration
Oxytocin / metabolism*
Pituitary Gland, Posterior / physiopathology
Rats, Brattleboro
Saline Solution, Hypertonic
Sodium Chloride / pharmacology
Vasopressins / pharmacology*
Grant Support
Reg. No./Substance:
0/Neurophysins; 0/Saline Solution, Hypertonic; 11000-17-2/Vasopressins; 16679-58-6/Deamino Arginine Vasopressin; 50-56-6/Oxytocin; 7647-14-5/Sodium Chloride

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