| Exogenous procalcitonin evokes a pro-inflammatory cytokine response. | |
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MedLine Citation:
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PMID: 20953970 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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OBJECTIVE AND DESIGN: Procalcitonin (ProCT) is increased in serum of septic patients and those with systemic inflammation. Endogenous levels of ProCT might influence the response of polymorphonuclear leukocytes (PMNs), independently of endotoxin, in clinical disease. SUBJECTS: Healthy human volunteers. TREATMENT: Recombinant human ProCT (rhProCT). METHODS: Whole blood and PMNs were exposed in vitro to exogenous rhProCT. Interleukin (IL)-6, IL-8, IL-10, IL-13, tumor necrosis factor-alpha (TNFα), IL-1β, and macrophage inflammatory protein (MIP)-1β (pg/ml) were measured by multiplex suspension bead-array immunoassay, and migration and phagocytosis were measured in PMNs. RESULTS: In a whole-blood model, a dose-dependent increase in IL-6, TNFα, and IL-1β of the cell-free supernatant was noted. Pre-incubation with ProCT, at doses consistent with clinical sepsis, resulted in a decrease in PMN migration without alteration in phagocytosis of Staphylococcus aureus or indirect measurements of bacterial killing. CONCLUSION: Clinically relevant levels of ProCT influence immunologic responses that may contribute to systemic inflammatory response and septic shock. |
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Authors:
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Angelike P Liappis; Kevin W Gibbs; Eric S Nylen; Bona Yoon; Richard H Snider; Baochong Gao; Kenneth L Becker |
Publication Detail:
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Type: Journal Article Date: 2010-10-17 |
Journal Detail:
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Title: Inflammation research : official journal of the European Histamine Research Society ... [et al.] Volume: 60 ISSN: 1420-908X ISO Abbreviation: Inflamm. Res. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9508160 Medline TA: Inflamm Res Country: Switzerland |
Other Details:
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Languages: eng Pagination: 203-7 Citation Subset: IM |
Affiliation:
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Medical Service and Section of Infectious Diseases, Veterans Affairs Medical Center, 50 Irving Street, NW 4A155, Washington, DC, USA, angelike.liappis@va.gov. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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