Document Detail


Exogenous peptide YY3-36 and Exendin-4 further decrease food intake, whereas octreotide increases food intake in rats after Roux-en-Y gastric bypass.
MedLine Citation:
PMID:  21694700     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Patients show an elevated postprandial satiety gut hormone release after Roux-en-Y Gastric bypass (gastric bypass). The altered gut hormone response appears to have a prominent role in the reduction of appetite and body weight (BW) after gastric bypass. Patients with insufficient BW loss after gastric bypass have an attenuated postprandial gut hormone response in comparison with patients who lost an adequate amount of BW. The effects of additional gut hormone administration after gastric bypass are unknown.
METHODS: The effects of peripheral administration of peptide YY3-36 (PYY3-36; 300 nmol kg(-1)), glucagon-like peptide-1 (GLP-1) analogue Exendin-4 (20 nmol kg(-1)) and somatostatin analogue octreotide (10 μg kg(-1)) on feeding and BW were evaluated in rats after gastric bypass.
RESULTS: Gastric bypass rats weighed (P<0.01) and ate less on postoperative day 5 (P<0.001) and thereafter, whereas postprandial plasma PYY and GLP-1 levels were higher compared with sham-operated controls (P<0.001). Administration of both PYY3-36 and Exendin-4 led to a further decrease in food intake in bypass rats compared with saline treatment (P=0.02 and P<0.0001, respectively). Similar reduction in food intake was observed in sham rats (P=0.02 and P<0.001, respectively). Exendin-4 treatment resulted in a significant BW loss in bypass (P=0.03) and sham rats (P=0.04). Subsequent treatment with octreotide led to an increase in food intake in bypass (P=0.007), but not in sham rats (P=0.87).
CONCLUSION: Peripheral administration of PYY3-36 and Exendin-4 reduces short-term food intake, whereas octreotide increases short-term food intake in rats after gastric bypass. The endogenous gut hormone response after gastric bypass can thus potentially be further enhanced by additional exogenous therapy with pharmacological doses of gut hormones in patients with insufficient weight loss or weight regain after surgery.
Authors:
W K Fenske; M Bueter; A D Miras; M A Ghatei; S R Bloom; C W le Roux
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-06-21
Journal Detail:
Title:  International journal of obesity (2005)     Volume:  36     ISSN:  1476-5497     ISO Abbreviation:  Int J Obes (Lond)     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-03-13     Completed Date:  2012-06-19     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  101256108     Medline TA:  Int J Obes (Lond)     Country:  England    
Other Details:
Languages:  eng     Pagination:  379-84     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Appetite Depressants / pharmacology
Appetite Regulation / drug effects*
Appetite Stimulants / pharmacology
Eating / drug effects*
Gastric Bypass*
Glucagon-Like Peptide 1 / metabolism
Hypoglycemic Agents / administration & dosage,  pharmacology*
Obesity / drug therapy*,  surgery
Octreotide / administration & dosage,  pharmacology*
Peptide Fragments
Peptide YY / administration & dosage,  pharmacology*
Peptides / administration & dosage,  pharmacology*
Postoperative Period
Rats
Satiation
Venoms / administration & dosage,  pharmacology*
Grant Support
ID/Acronym/Agency:
G0902002//Medical Research Council; G7811974//Medical Research Council; //Medical Research Council
Chemical
Reg. No./Substance:
0/Appetite Depressants; 0/Appetite Stimulants; 0/Hypoglycemic Agents; 0/Peptide Fragments; 0/Peptides; 0/Venoms; 106388-42-5/Peptide YY; 123583-37-9/peptide YY (3-36); 89750-14-1/Glucagon-Like Peptide 1; 9P1872D4OL/exenatide; RWM8CCW8GP/Octreotide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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