| Exogenous nitric oxide prevents cardiovascular collapse during hemorrhagic shock. | |
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MedLine Citation:
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PMID: 21342744 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study investigated the systemic and microvascular hemodynamic changes related to increased nitric oxide (NO) availability following significant hemorrhage, made available by administration of NO releasing nanoparticles (NO-nps). Hemodynamic responses to hemorrhagic shock were studied in the hamster window chamber. Acute hemorrhage was induced by arterial controlled bleeding of 50% of blood volume, and the resulting hemodynamic parameters were followed over 90 min. Exogenous NO was administered in the form of NO-nps (5mg/kg suspended in 50 μl saline) 10 min following induced hemorrhage. Control groups received equal dose of NO free nanoparticles (Control-nps) and Vehicle solution. Animals treated with NO-nps partially maintained systemic and microvascular function during hypovolemic shock compared to animals treated with Control-nps or the Vehicle (50 μl saline). The continuous NO released by the NO-nps reverted arteriolar vasoconstriction, partially recovered both functional capillary density and microvascular blood flows. Additionally, NO supplementation post hemorrhage prevented cardiac decompensation, and thereby maintained and stabilized the heart rate. Paradoxically, the peripheral vasodilation induced by the NO-nps did not decrease blood pressure, and combined with NO's effects on vascular resistance, NO-nps promoted intravascular pressure redistribution and blood flow, avoiding tissue ischemia. Therefore, by increasing NO availability with NO-nps during hypovolemic shock, it is possible that cardiac stability and microvascular perfusion can be preserved, ultimately increasing survivability and local tissue viability, and reducing hemorrhagic shock sequelae. The relevance, stability, and efficacy of exogenous NO therapy in the form of NO-nps will potentially facilitate the intended use in battlefield and trauma situations. |
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Authors:
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Parimala Nachuraju; Adam J Friedman; Joel M Friedman; Pedro Cabrales |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-02-20 |
Journal Detail:
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Title: Resuscitation Volume: 82 ISSN: 1873-1570 ISO Abbreviation: Resuscitation Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-04-25 Completed Date: 2011-11-15 Revised Date: 2012-05-02 |
Medline Journal Info:
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Nlm Unique ID: 0332173 Medline TA: Resuscitation Country: Ireland |
Other Details:
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Languages: eng Pagination: 607-13 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, NY, United States. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Flow Velocity / drug effects, physiology Cricetinae Disease Models, Animal Free Radical Scavengers / administration & dosage* Heart Arrest / etiology, physiopathology, prevention & control* Injections, Intravenous Male Mesocricetus Microcirculation / drug effects* Nanoparticles Nitric Oxide / administration & dosage* Shock, Hemorrhagic / complications, drug therapy*, physiopathology Treatment Outcome |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL062318-04/HL/NHLBI NIH HHS; R01 HL062354-04/HL/NHLBI NIH HHS; R01 HL062354-08/HL/NHLBI NIH HHS; R01 HL064395-10/HL/NHLBI NIH HHS; R01-HL62354/HL/NHLBI NIH HHS; R24 HL064395-05/HL/NHLBI NIH HHS; R24-HL64395/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Free Radical Scavengers; 10102-43-9/Nitric Oxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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