| Exogenous intravascular nitric oxide enhances ventricular function after hemodilution with plasma expander. | |
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MedLine Citation:
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PMID: 22056371 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: This study evaluated the hypothesis that exogenous nitric oxide (NO) supplementation during acute hemodilution with plasma expander (PE) provides beneficial effects on cardiac function. MAIN METHODS: Acute hemodilution in golden Syrian hamsters was induced by a 40% of blood volume exchange with dextran 70 kDa. Intravascular NO supplementation after hemodilution was accomplished with a NO donor, diethylenetriamine NONOate (DETA NONOate). The test group was treated with DETA NONOate, while the control group received only vehicle. Left ventricular cardiac function was studied using pressure-volume measurements obtained with a miniaturized conductance catheter. KEY FINDINGS: Cardiac output increased to 122±5% and 107±1% of the baseline in the group treated with NO donor and the vehicle group, respectively. Stroke work per stroke volume (SW/SV) after hemodilution reduced to 90% of the baseline and the NO donor significantly reduced SW/SV compared to the vehicle. The minimum rate of pressure change (dP/dt(min)) was significantly lower in animals treated with the NO donor compared to vehicle treated animals. Systemic vascular resistance (SVR) decreased to 62±5% of the baseline in the NO donor group whereas the vehicle group SVR decreased to 83±5% of the baseline. Using intravital microscopy analysis of microvessel in the dorsal skinfold window chamber, we established that the NO donor group induced significant vasodilation compared to the vehicle group. SIGNIFICANCE: NO supplementation in an acute hemodilution with PE has beneficial effects on cardiac performance. However, the NO supplementation effects with a NO donor are dose-independent and short-lasting. |
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Authors:
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Surapong Chatpun; Pedro Cabrales |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural Date: 2011-10-26 |
Journal Detail:
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Title: Life sciences Volume: 90 ISSN: 1879-0631 ISO Abbreviation: Life Sci. Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2011-12-26 Completed Date: 2012-02-14 Revised Date: 2013-02-20 |
Medline Journal Info:
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Nlm Unique ID: 0375521 Medline TA: Life Sci Country: Netherlands |
Other Details:
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Languages: eng Pagination: 39-46 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093-0412, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Volume / drug effects, physiology Cricetinae Hemodilution / adverse effects, methods* Infusions, Intra-Arterial Infusions, Intravenous Male Mesocricetus Nitric Oxide / administration & dosage* Nitric Oxide Donors / administration & dosage Plasma Substitutes / administration & dosage*, adverse effects Ventricular Function, Left / drug effects*, physiology |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL052684-13/HL/NHLBI NIH HHS; R01 HL062354-08/HL/NHLBI NIH HHS; R01 HL064395-10/HL/NHLBI NIH HHS; R01-HL52684/HL/NHLBI NIH HHS; R01-HL62354/HL/NHLBI NIH HHS; R24 HL064395-05/HL/NHLBI NIH HHS; R24-HL64395/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Nitric Oxide Donors; 0/Plasma Substitutes; 10102-43-9/Nitric Oxide |
| Comments/Corrections | |
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