Document Detail

Exogenous intravascular nitric oxide enhances ventricular function after hemodilution with plasma expander.
MedLine Citation:
PMID:  22056371     Owner:  NLM     Status:  MEDLINE    
AIMS: This study evaluated the hypothesis that exogenous nitric oxide (NO) supplementation during acute hemodilution with plasma expander (PE) provides beneficial effects on cardiac function.
MAIN METHODS: Acute hemodilution in golden Syrian hamsters was induced by a 40% of blood volume exchange with dextran 70 kDa. Intravascular NO supplementation after hemodilution was accomplished with a NO donor, diethylenetriamine NONOate (DETA NONOate). The test group was treated with DETA NONOate, while the control group received only vehicle. Left ventricular cardiac function was studied using pressure-volume measurements obtained with a miniaturized conductance catheter.
KEY FINDINGS: Cardiac output increased to 122±5% and 107±1% of the baseline in the group treated with NO donor and the vehicle group, respectively. Stroke work per stroke volume (SW/SV) after hemodilution reduced to 90% of the baseline and the NO donor significantly reduced SW/SV compared to the vehicle. The minimum rate of pressure change (dP/dt(min)) was significantly lower in animals treated with the NO donor compared to vehicle treated animals. Systemic vascular resistance (SVR) decreased to 62±5% of the baseline in the NO donor group whereas the vehicle group SVR decreased to 83±5% of the baseline. Using intravital microscopy analysis of microvessel in the dorsal skinfold window chamber, we established that the NO donor group induced significant vasodilation compared to the vehicle group.
SIGNIFICANCE: NO supplementation in an acute hemodilution with PE has beneficial effects on cardiac performance. However, the NO supplementation effects with a NO donor are dose-independent and short-lasting.
Surapong Chatpun; Pedro Cabrales
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2011-10-26
Journal Detail:
Title:  Life sciences     Volume:  90     ISSN:  1879-0631     ISO Abbreviation:  Life Sci.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2011-12-26     Completed Date:  2012-02-14     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  39-46     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093-0412, USA.
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MeSH Terms
Blood Volume / drug effects,  physiology
Hemodilution / adverse effects,  methods*
Infusions, Intra-Arterial
Infusions, Intravenous
Nitric Oxide / administration & dosage*
Nitric Oxide Donors / administration & dosage
Plasma Substitutes / administration & dosage*,  adverse effects
Ventricular Function, Left / drug effects*,  physiology
Grant Support
R01 HL052684-13/HL/NHLBI NIH HHS; R01 HL062354-08/HL/NHLBI NIH HHS; R01 HL064395-10/HL/NHLBI NIH HHS; R01-HL52684/HL/NHLBI NIH HHS; R01-HL62354/HL/NHLBI NIH HHS; R24 HL064395-05/HL/NHLBI NIH HHS; R24-HL64395/HL/NHLBI NIH HHS
Reg. No./Substance:
0/Nitric Oxide Donors; 0/Plasma Substitutes; 10102-43-9/Nitric Oxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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