Document Detail


Exogenous hormones and colorectal cancer risk in Canada: associations stratified by clinically defined familial risk of cancer.
MedLine Citation:
PMID:  17549595     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: This work assessed associations between colorectal cancer risk and postmenopausal/contraceptive hormones; subgroup analyses included women with a clinically defined family history of cancer. METHODS: A population based case-control study of incident colorectal cancer was conducted among women aged 20-74 years in Ontario and Newfoundland & Labrador, Canada. Incident cases (n = 1,404) were selected from provincial cancer registries and controls (n = 1,203) were identified through property records, and other means, between January 1997 and April 2006. Family history of cancer, exogenous hormone-use, and other risk factors were collected via self-administered questionnaires. Multivariate unconditional logistic regression analyses were used to estimate odds ratios (ORs) and corresponding 95% confidence intervals (CIs). RESULTS: Decreased risks of colorectal cancer were observed with ever-users of: hormonal contraceptives (OR: 0.77; CI: 0.65-0.91), estrogen-only postmenopausal hormones (OR: 0.60; CI: 0.47-0.75), and estrogen-progestin postmenopausal hormones (OR: 0.70; CI: 0.52-0.95). Risk estimates were similar between women with and without a strong familial history of cancer. Age at initiation of hormonal contraceptives was associated with colorectal cancer risk; women who initiated use at younger ages (age <22 years: OR: 0.60; CI: 0.47-0.77) experienced a greater reduced risk of disease than women who initiated use at later ages (age 30+: OR: 0.92; CI: 0.68-1.24; p (trend): 0.0026). CONCLUSIONS: These results indicate that exogenous hormone-use is linked with reduced risk of colorectal cancer among women with a strong familial risk of cancer, consistent with observations on population samples of sporadic colorectal cancer cases. A potential age-effect for use of hormonal contraceptives warrants further attention.
Authors:
Peter T Campbell; Polly Newcomb; Steven Gallinger; Michelle Cotterchio; John R McLaughlin
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2007-06-05
Journal Detail:
Title:  Cancer causes & control : CCC     Volume:  18     ISSN:  0957-5243     ISO Abbreviation:  Cancer Causes Control     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-06-25     Completed Date:  2007-08-29     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  9100846     Medline TA:  Cancer Causes Control     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  723-33     Citation Subset:  IM    
Affiliation:
Prosserman Centre for Health Research, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada. ptcampbe@fhcrc.org
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Case-Control Studies
Colorectal Neoplasms / etiology*,  genetics*
Contraceptive Agents, Female / adverse effects*
Estrogen Replacement Therapy / adverse effects*
Female
Genetic Predisposition to Disease*
Humans
Middle Aged
Risk Factors
Grant Support
ID/Acronym/Agency:
CA-96-011/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Contraceptive Agents, Female

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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