| Exogenous amino acids stimulate human muscle anabolism without interfering with the response to mixed meal ingestion. | |
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MedLine Citation:
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PMID: 15572657 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We sought to determine whether ingestion of a between-meal supplement containing 30 g of carbohydrate and 15 g of essential amino acids (CAA) altered the metabolic response to a nutritionally mixed meal in healthy, recreationally active male volunteers. A control group (CON; n = 6, 38 +/- 8 yr, 86 +/- 10 kg, 179 +/- 3 cm) received a liquid mixed meal [protein, 23.4 +/- 1.0 g (essential amino acids, 14.7 +/- 0.7 g); carbohydrate, 126.6 +/- 4.0 g; fat, 30.3 +/- 2.8 g] every 5 h (0830, 1330, 1830). The experimental group (SUP; n = 7, 36 +/- 10 yr, 87 +/- 12 kg, 180 +/- 3 cm) consumed the same meals but, in addition, were given CAA supplements (1100, 1600, 2100). Net phenylalanine balance (NB) and fractional synthetic rate (FSR) were calculated during a 16-h primed constant infusion of L-[ring-2H5]phenylalanine. Ingestion of a combination of CAA supplements and meals resulted in a greater mixed muscle FSR than ingestion of the meals alone (SUP, 0.099 +/- 0.008; CON, 0.076 +/- 0.005%/h; P < 0.05). Both groups experienced an improvement in NB after the morning (SUP, -2.2 +/- 3.3; CON, -1.5 +/- 3.5 nmol x min(-1) x 100 ml leg volume(-1)) and evening meals (SUP, -9.7 +/- 4.3; CON, -6.7 +/- 4.1 nmol x min(-1) x 100 ml leg volume(-1)). NB after CAA ingestion was significantly greater than after the meals, with values of 40.2 +/- 8.5 nmol x min(-1) x 100 ml leg volume(-1). These data indicate that CAA supplementation produces a greater anabolic effect than ingestion of intact protein but does not interfere with the normal metabolic response to a meal. |
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Authors:
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Douglas Paddon-Jones; Melinda Sheffield-Moore; Asle Aarsland; Robert R Wolfe; Arny A Ferrando |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. Date: 2004-11-30 |
Journal Detail:
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Title: American journal of physiology. Endocrinology and metabolism Volume: 288 ISSN: 0193-1849 ISO Abbreviation: Am. J. Physiol. Endocrinol. Metab. Publication Date: 2005 Apr |
Date Detail:
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Created Date: 2005-03-18 Completed Date: 2005-04-12 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 100901226 Medline TA: Am J Physiol Endocrinol Metab Country: United States |
Other Details:
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Languages: eng Pagination: E761-7 Citation Subset: IM; S |
Affiliation:
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Department of Surgery, The University of Texas Medical Branch, Galveston, TX 77550, USA. djpaddon@utmb.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amino Acids, Essential / administration & dosage*, blood, metabolism Dietary Carbohydrates / administration & dosage, metabolism Dietary Proteins / administration & dosage*, metabolism Dietary Supplements* Eating / physiology Feeding Behavior / physiology Humans Male Middle Aged Muscle Proteins / metabolism* Muscle, Skeletal / drug effects*, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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M01-RR-00073/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids, Essential; 0/Dietary Carbohydrates; 0/Dietary Proteins; 0/Muscle Proteins |
| Investigator | |
Investigator/Affiliation:
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R R Wolfe / U TX Med Br, Galveston |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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