Document Detail

Exogenous Hydrogen Sulfide (H(2)S) Reduces Blood Pressure and Prevents the Progression of Diabetic Nephropathy in Spontaneously Hypertensive Rats.
MedLine Citation:
PMID:  22229751     Owner:  NLM     Status:  Publisher    
Abstract The coexistence of hypertension and diabetes results in the rapid development of nephropathy. Hydrogen sulfide (H(2)S) is claimed to control the vascular and renal functions. This study tested the hypothesis that exogenous H(2)S lowers the blood pressure and decreases the progression of nephropathy in spontaneously hypertensive rats (SHR) that were diabetic. Eighteen SHR were divided into three groups: SHR, SHR diabetic, and SHR diabetic treated with a group of Wistar-Kyoto rats serving as normotensive nondiabetic control. Diabetes was induced with streptozotocin (STZ) in two groups and one diabetic group received sodium hydrosulfide (NaHS), a H(2)S donor for 5 weeks. Blood pressure was measured in conscious and anesthetized states and renal cortical blood perfusion in acute studies. Plasma and urinary H(2)S levels, creatinine concentrations, and electrolytes were measured on three different occasions throughout the 35-day period. Diabetic SHR had higher blood pressure, lower plasma and urinary H(2)S levels, and renal dysfunction as evidenced by increased plasma creatinine, creatinine clearance, and decreased urinary sodium-to-potassium ratio and renal cortical blood perfusion. NaHS reduced blood pressure, increased H(2)S levels in plasma and urinary excretion, and reversed the STZ-induced renal dysfunction. The findings of this study suggest that the administration of exogenous H(2)S lowers the blood pressure and confers protection against the progression of STZ-induced nephropathy in SHR.
Fiaz Ud Din Ahmad; Munavvar Abdul Sattar; Hassaan Anwer Rathore; Mohammed Hadi Abdullah; Samual Tan; Nor Azizan Abdullah; Edward James Johns
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-9
Journal Detail:
Title:  Renal failure     Volume:  -     ISSN:  1525-6049     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701128     Medline TA:  Ren Fail     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Physiology, School of Pharmaceutical Sciences, Universiti Sains Malaysia , Penang , Malaysia.
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