Document Detail


Exocrine pancreatic insufficiency syndrome in CBA/J mice. III. Pathological and genetic analysis.
MedLine Citation:
PMID:  873127     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A clinical and histopathological description of exocrine pancreatic insufficiency syndrome in CBA/J mice is presented. Amelioration of clinical symptoms by pancreatic enzyme replacement therapy is described, as are breeding experiments designed to test the hypothesis that the etiology of this syndrome is a recessive mutation. Our failure to propagate the expected numbers of animals with the syndrome by genetic means leads us to the conclusion that it is not transmitted as an autosomal recessive mutation. Our finding of focal histological lesions of the exocrine pancreas in large numbers of clinically normal CBA/J mice suggests that the CBA/J genetic background is some way predisposes this strain to the spontaneous necrosis and atrophy of exocrine cells that is pathognomonic of this disease.
Authors:
E H Leiter; T Cunliffe-Beamer
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Gastroenterology     Volume:  73     ISSN:  0016-5085     ISO Abbreviation:  Gastroenterology     Publication Date:  1977 Aug 
Date Detail:
Created Date:  1977-08-25     Completed Date:  1977-08-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  260-6     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Atrophy
Female
Glucose Tolerance Test
Insulin / secretion
Male
Mice
Mice, Inbred CBA*
Necrosis
Pancreas / pathology*
Pancreatic Diseases* / genetics,  pathology,  transmission
Pancreatic Juice / secretion*
Trypsin / secretion
Chemical
Reg. No./Substance:
11061-68-0/Insulin; EC 3.4.21.4/Trypsin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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