Document Detail


Exocrine pancreatic function in the early phase of human acute pancreatitis.
MedLine Citation:
PMID:  7537386     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Little is known about exocrine pancreatic function during human acute pancreatitis. We aimed to evaluate interdigestive exocrine pancreatic secretion and pancreatic polypeptide (PP) release during the early phase of acute pancreatitis in humans. METHODS: Eight patients with acute pancreatitis (six biliary, one alcoholic, and one idiopathic acute pancreatitis) were studied within 72 h from the onset of symptoms. Four patients had necrotizing and four had edematous acute pancreatitis. Normal values were obtained from 26 normal subjects matched by sex and age. Interdigestive pancreatic secretion was studied by a duodenal intubation perfusion technique. Enzyme output was calculated for consecutive 15-min periods over 3-4 h and expressed as units per hour within a secretion cycle and units per hour around a secretion peak. Plasma PP concentrations were measured by radioimmunoassay in 15-min intervals. RESULTS: All variables studied were similar in patients with acute pancreatitis and in controls. PP release in acute pancreatitis was maintained in a normal cyclical pattern closely related to the secretory cycles. CONCLUSIONS: Interdigestive exocrine pancreatic secretion in the early phase of mild to moderate acute pancreatitis in humans remains within the normal range. This finding provides a rational basis for early therapeutic inhibition of pancreatic secretion in human acute pancreatitis.
Authors:
J E Domínguez-Muñoz; O Pieramico; M Büchler; P Malfertheiner
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian journal of gastroenterology     Volume:  30     ISSN:  0036-5521     ISO Abbreviation:  Scand. J. Gastroenterol.     Publication Date:  1995 Feb 
Date Detail:
Created Date:  1995-05-30     Completed Date:  1995-05-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0060105     Medline TA:  Scand J Gastroenterol     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  186-91     Citation Subset:  IM    
Affiliation:
Dept. of Internal Medicine, University Hospital of Ulm, Germany.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Amylases / metabolism
Chymotrypsin / metabolism
Female
Humans
Intubation, Gastrointestinal
Male
Middle Aged
Pancreas / physiopathology,  secretion*
Pancreatic Polypeptide / metabolism*
Pancreatitis / physiopathology*
Radioimmunoassay
Reference Values
Time Factors
Trypsin / metabolism
Chemical
Reg. No./Substance:
59763-91-6/Pancreatic Polypeptide; EC 3.2.1.-/Amylases; EC 3.4.21.1/Chymotrypsin; EC 3.4.21.4/Trypsin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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