Document Detail


Exocrine pancreatic function in critically ill patients: septic shock versus non-septic patients.
MedLine Citation:
PMID:  10834684     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine the exocrine pancreatic function in critically ill patients. DESIGN: Prospective cohort study. SETTING: Medical intensive care unit. PATIENTS: A total of 18 critically ill patients (11 patients with septic shock according to the criteria of the American College of Chest Physicians/Society of Critical Care Medicine, 7 nonseptic patients). The results obtained in these subjects were compared with the data obtained in seven healthy volunteers. INTERVENTIONS: Examination of exocrine pancreatic function was done by means of a cholecystokinin-secretin test. Intravenous stimulation of the exocrine pancreas with cholecystokinin and secretin (1 unit/kg body weight/hr each) and aspiration of duodenal fluid by a gastroscopically inserted oroduodenal tube was done during a period of 1 hr. MEASUREMENTS AND MAIN RESULTS: The content of amylase, chymotrypsin, and trypsin in aspirated duodenal fluid was significantly reduced in patients with septic shock compared with nonseptic patients as well as healthy subjects (p < .01). The volume of aspirated fluid was significantly reduced in patients with septic shock compared with healthy controls (p = .03), but not in nonseptic patients. The content of bicarbonate was not statistically different in the three groups. No significant correlation was to find between variables of exocrine pancreatic function and Acute Physiology and Chronic Health Evaluation III score, sepsis-related organ failure assessment score, systolic arterial pressure and mean arterial pressure in septic shock patients. Positive end-expiratory pressure was significantly correlated with the content of trypsin (r2 = 0.52; p = .02). Postmortem examinations of five septic patients who died during the intensive care stay did not reveal gross morphologic alterations of pancreatic tissue. CONCLUSIONS: The study shows two pancreatic enzyme systems, namely, amylase as a carbohydrate splitting enzyme and the proteolytic enzymes trypsin and chymotrypsin, strongly affected in critically ill patients with septic shock.
Authors:
B Tribl; C Madl; P R Mazal; B Schneider; S Spitzauer; H Vogelsang; A Gangl
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Critical care medicine     Volume:  28     ISSN:  0090-3493     ISO Abbreviation:  Crit. Care Med.     Publication Date:  2000 May 
Date Detail:
Created Date:  2000-06-08     Completed Date:  2000-06-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0355501     Medline TA:  Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1393-8     Citation Subset:  AIM; IM    
Affiliation:
Clinic of Internal Medicine IV--Department of Gastroenterology and Hepatology, University of Vienna, Austria.
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MeSH Terms
Descriptor/Qualifier:
Aged
Amylases / metabolism
Cholecystokinin / diagnostic use
Chymotrypsin / metabolism
Cohort Studies
Exocrine Pancreatic Insufficiency / diagnosis*,  physiopathology
Female
Humans
Intensive Care*
Male
Middle Aged
Pancreas / physiopathology
Pancreatic Function Tests*
Prospective Studies
Secretin / diagnostic use
Shock, Septic / diagnosis*,  physiopathology
Trypsin / metabolism
Chemical
Reg. No./Substance:
1393-25-5/Secretin; 9011-97-6/Cholecystokinin; EC 3.2.1.-/Amylases; EC 3.4.21.1/Chymotrypsin; EC 3.4.21.4/Trypsin

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