Document Detail

Exocrine pancreatic function as determined in a same-day test with use of bentiromide and p-aminosalicylic acid.
MedLine Citation:
PMID:  3486726     Owner:  NLM     Status:  MEDLINE    
We describe a new approach to the bentiromide test of exocrine pancreatic function, p-Aminosalicylic acid (PAS), a compound closely related to the bentiromide fragment p-aminobenzoic acid (PABA), is used as a marker of the pharmacokinetic behavior of PABA to derive a PABA excretion index. This index is identical to that derived with [14C]-PABA. Concentrations of both PABA and PAS are measured in urine by "high-performance" liquid chromatography, which avoids the drug interferences encountered with established assays of PABA. We discuss the practical and diagnostic advantages of this new approach to the bentiromide test.
J D Berg; I M Chesner; R A Allen-Narker; B M Buckley; N Lawson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical chemistry     Volume:  32     ISSN:  0009-9147     ISO Abbreviation:  Clin. Chem.     Publication Date:  1986 Jun 
Date Detail:
Created Date:  1986-07-03     Completed Date:  1986-07-03     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9421549     Medline TA:  Clin Chem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1010-2     Citation Subset:  IM    
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MeSH Terms
4-Aminobenzoic Acid / analogs & derivatives,  diagnostic use*,  metabolism,  urine
Aminobenzoic Acids / diagnostic use*
Aminosalicylic Acid / diagnostic use*,  metabolism,  urine
Aminosalicylic Acids / diagnostic use*
Middle Aged
Pancreas / physiology*
Pancreatic Function Tests*
Reg. No./Substance:
0/Aminobenzoic Acids; 0/Aminosalicylic Acids; 150-13-0/4-Aminobenzoic Acid; 37106-97-1/bentiromide; 65-49-6/Aminosalicylic Acid

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