Document Detail


Exocarpic acid inhibits mycolic acid biosynthesis in Mycobacterium tuberculosis.
MedLine Citation:
PMID:  20506078     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Exocarpic acid (13 E-octadecene-9,11-diynoic acid) from Exocarpos latifolius R.Br. (Santalaceae) was previously shown to have specific antimycobacterial activity. Microarray data suggested inhibition of fatty acid metabolism as a potential mode of action. Experiments designed to elucidate the mechanism of action showed that exocarpic acid was effective at inhibition of mycolic acid biosynthesis and did not act by dissipating the proton gradient in treated M. tuberculosis. Amide derivatives of exocarpic acid displayed similar properties to exocarpic acid, while other polyacetylenic fatty acids varied in their effects on mycolic acid biosynthesis.
Authors:
Michael Koch; Tim S Bugni; Mohammad Sondossi; Chris M Ireland; Louis R Barrows
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-05-26
Journal Detail:
Title:  Planta medica     Volume:  76     ISSN:  1439-0221     ISO Abbreviation:  Planta Med.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0066751     Medline TA:  Planta Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1678-82     Citation Subset:  IM    
Copyright Information:
© Georg Thieme Verlag KG Stuttgart · New York.
Affiliation:
Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah 84112, USA.
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MeSH Terms
Descriptor/Qualifier:
Grant Support
ID/Acronym/Agency:
5U01TW006671-05/TW/FIC NIH HHS

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