Document Detail

Existence of a silent gene for pseudocholinesterase in a Trinidad population.
MedLine Citation:
PMID:  7900379     Owner:  NLM     Status:  MEDLINE    
Although the values reported were higher than those reported for Caucasians, differences in dibucaine number for pseudocholinesterase values among the three ethnic groups in Trinidad and Tobago, were not significant. Eight individuals had intermediate dibucaine number values between 40 and 70; one of them was African, 3 were East Indians, and 4 Mixed. Two of the Mixed group were of Portuguese lineage and had significantly lower dibucaine numbers and enzyme concentration. Two sisters of East Indian origin had an inestimable dibucaine number and their pseudocholinesterase values were just detectable, suggesting the presence of a 'silent gene' for pseudocholinesterase. These studies, which are being extended, suggest that the dibucaine number should be estimated prior to succinylcholine administration in patients in Trinidad and Tobago who are at risk of apnoea.
L M Pinto Pereira; Y Clement; B V Telang; H McFarlane
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The West Indian medical journal     Volume:  43     ISSN:  0043-3144     ISO Abbreviation:  West Indian Med J     Publication Date:  1994 Dec 
Date Detail:
Created Date:  1995-04-27     Completed Date:  1995-04-27     Revised Date:  2008-03-10    
Medline Journal Info:
Nlm Unique ID:  0417410     Medline TA:  West Indian Med J     Country:  JAMAICA    
Other Details:
Languages:  eng     Pagination:  140-2     Citation Subset:  IM    
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MeSH Terms
Aged, 80 and over
Child, Preschool
Chromosomes, Human, Pair 3
Cross-Cultural Comparison*
Developing Countries*
Gene Frequency
Genes, Recessive*
Genetics, Population
Middle Aged
Prospective Studies
Pseudocholinesterase / deficiency,  genetics*
Trinidad and Tobago
Reg. No./Substance:
EC 3.1.1.-/Pseudocholinesterase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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