Document Detail

Existence and distribution of melanocytes and HMB-45-positive cells in the human minor salivary glands.
MedLine Citation:
PMID:  10692173     Owner:  NLM     Status:  MEDLINE    
The existence and distribution of melanocytes in the human minor salivary glands were investigated in a series of autopsy and biopsy materials. The cells with the following characteristics were regarded as melanocytes; spindle-shaped or dendritic cells with fine granular pigments: (i) stained brownish-black by hematoxylin-eosin stain, and black by Masson-Fontana's silver impregnation method; and (ii) disappeared after treatment with peroxide and potassium permanganate solution. In addition, the expression of antigen identified by anti-HMB-45 antibody in serial sections with melanocytes was examined. Melanocytes were found in eight (1.8%) of 445 cases, and there was no relationship between the existence of melanocytes and significant diseases of the subjects. Various numbers of melanocytes were distributed in fibrous tissue around the interlobular ducts, intralobular ducts and acini, but were not in direct contact with the epithelia. Neither melanocytes nor melanin granules were found in the salivary gland epithelia. HMB-45-positive cells without intracytoplasmic fine granules were found solitarily or in small groups in periductal and periacinar fibrous tissues with or without slight infiltration of small mononuclear cells.
Y Takeda
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pathology international     Volume:  50     ISSN:  1320-5463     ISO Abbreviation:  Pathol. Int.     Publication Date:  2000 Jan 
Date Detail:
Created Date:  2000-05-09     Completed Date:  2000-05-09     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9431380     Medline TA:  Pathol Int     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  15-9     Citation Subset:  IM    
Department of Oral Pathology, School of Dentistry, Iwate Medical University, Morioka, Japan.
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MeSH Terms
Antigens, Neoplasm
Melanocytes / metabolism*,  pathology
Middle Aged
Neoplasm Proteins / metabolism*
Salivary Gland Diseases / metabolism,  pathology
Salivary Glands, Minor / metabolism*,  pathology
Reg. No./Substance:
0/Antigens, Neoplasm; 0/Neoplasm Proteins; 0/melanoma-specific antigens

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