Document Detail


Existence of a digitalis-like compound in the human fetus.
MedLine Citation:
PMID:  1647221     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Digoxin-like inhibitors of Na+,K(+)-ATPase have been implicated in several pathophysiological problems in the perinatal period. Aqueous endogenous digoxin-like immunoreactive substance (DLIS) was extracted from 9 different organs of a 24-week-old human fetus whose mother died after paraquat poisoning. The results indicate that this endogenous DLIS has a wide distribution in fetal tissues. The highest levels were found in gut and adrenals, and there was a correlation between these high levels and the inhibition of Na+,K(+)-ATPase. The hypothesis that DLIS originated in the fetus is of particular relevance.
Authors:
X Guédeney; C Chanez; J M Scherrmann
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biology of the neonate     Volume:  59     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  1991  
Date Detail:
Created Date:  1991-07-29     Completed Date:  1991-07-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  133-8     Citation Subset:  IM    
Affiliation:
INSERM U 26, Hôpital Fernand-Widal, Paris, France.
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MeSH Terms
Descriptor/Qualifier:
Blood Proteins / analysis*,  pharmacology
Cardenolides
Cross Reactions
Digoxin / analysis
Fetus / chemistry*,  enzymology
Humans
Radioimmunoassay
Saponins*
Sodium-Potassium-Exchanging ATPase / antagonists & inhibitors
Chemical
Reg. No./Substance:
0/Blood Proteins; 0/Cardenolides; 0/Saponins; 0/digoxin-like factors; 20830-75-5/Digoxin; EC 3.6.3.9/Sodium-Potassium-Exchanging ATPase

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