| Existence of a digitalis-like compound in the human fetus. | |
| | |
MedLine Citation:
|
PMID: 1647221 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Digoxin-like inhibitors of Na+,K(+)-ATPase have been implicated in several pathophysiological problems in the perinatal period. Aqueous endogenous digoxin-like immunoreactive substance (DLIS) was extracted from 9 different organs of a 24-week-old human fetus whose mother died after paraquat poisoning. The results indicate that this endogenous DLIS has a wide distribution in fetal tissues. The highest levels were found in gut and adrenals, and there was a correlation between these high levels and the inhibition of Na+,K(+)-ATPase. The hypothesis that DLIS originated in the fetus is of particular relevance. |
| | |
Authors:
|
X Guédeney; C Chanez; J M Scherrmann |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Biology of the neonate Volume: 59 ISSN: 0006-3126 ISO Abbreviation: Biol. Neonate Publication Date: 1991 |
Date Detail:
|
Created Date: 1991-07-29 Completed Date: 1991-07-29 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0247551 Medline TA: Biol Neonate Country: SWITZERLAND |
Other Details:
|
Languages: eng Pagination: 133-8 Citation Subset: IM |
Affiliation:
|
INSERM U 26, Hôpital Fernand-Widal, Paris, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Blood Proteins
/
analysis*,
pharmacology Cardenolides Cross Reactions Digoxin / analysis Fetus / chemistry*, enzymology Humans Radioimmunoassay Saponins* Sodium-Potassium-Exchanging ATPase / antagonists & inhibitors |
| Chemical | |
Reg. No./Substance:
|
0/Blood Proteins; 0/Cardenolides; 0/Saponins; 0/digoxin-like factors; 20830-75-5/Digoxin; EC 3.6.3.9/Sodium-Potassium-Exchanging ATPase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The nature of spontaneous and induced mutagenesis in a genetically unstable mutator strain of Drosop...
Next Document: Sleep disruption alters nocturnal ACTH and cortisol secretory patterns.