Document Detail

Existence of beta(3)-adrenoceptors in rat heart: functional implications.
MedLine Citation:
PMID:  17600560     Owner:  NLM     Status:  MEDLINE    
1. beta(3)-Adrenoceptors (AR) have been reported to be present in numerous species, where they mediate multiple responses. 2. The aim of the present study was to determine whether beta(3)-AR are present in intact rat heart and the functional implications of beta(3)-AR stimulation. The response to the cardiac beta(3)-AR-selective agonist BRL37344 was expressed as the percentage of values measured at baseline. 3. BRL37344 induced dose-dependent negative inotropic effects at concentrations ranging from 10(-11) to 10(-7) mol/L. BRL37344 (10(-8) mol/L) induced a decrease of left ventricular developed pressure (LVDP) from 127 +/- 5 to 89 +/- 16 mmHg (69 +/- 15%; P < 0.01) and +dP/dt from 2594 +/- 59 to 1885 +/- 50 mmHg/s (72 +/- 8%; P < 0.01). Moreover, a significant reduction of -dP/dt from 2176 +/- 42 to 1458 +/- 43 mmHg/s (67 +/- 8%; P < 0.01) was observed. The BRL37344 dose-response curves were not altered by nadolol (10(-5) mol/L), a potent beta(1)- and beta(2)-AR antagonist, but were completely suppressed by the addition of SR59230A (10(-5) mol/L), a potent beta(3)-AR antagonist. 4. The present study provides functional evidence for the presence of beta(3)-AR in rat hearts and shows, for the first time, that a highly specific beta(3)-AR antagonist can block the attenuation of LVDP caused by the specific beta(3)-AR agonist BRL37344 in rat beating hearts.
J Barbier; C Mouas; F Rannou-Bekono; F Carré
Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Clinical and experimental pharmacology & physiology     Volume:  34     ISSN:  0305-1870     ISO Abbreviation:  Clin. Exp. Pharmacol. Physiol.     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-06-29     Completed Date:  2007-08-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0425076     Medline TA:  Clin Exp Pharmacol Physiol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  796-8     Citation Subset:  IM    
EA 1274, Laboratory of Physiology and Biomechanics of Muscular Exercise, UFR-APS, University of Rennes 2, Rennes, France.
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MeSH Terms
Adrenergic beta-Agonists / pharmacology
Adrenergic beta-Antagonists / pharmacology
Dose-Response Relationship, Drug
Ethanolamines / pharmacology
Heart / drug effects,  physiology*
Myocardial Contraction
Myocardium / metabolism*
Propanolamines / pharmacology
Rats, Wistar
Receptors, Adrenergic, beta-3 / drug effects*,  metabolism*
Ventricular Function, Left* / drug effects
Ventricular Pressure
Reg. No./Substance:
0/Adrenergic beta-Agonists; 0/Adrenergic beta-Antagonists; 0/Ethanolamines; 0/Propanolamines; 0/Receptors, Adrenergic, beta-3; 0/SR 59230A; 114333-71-0/BRL 37344

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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