| Exhaustive genotyping of the interleukin-1 family genes and associations with AIDS progression in a French cohort. | |
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MedLine Citation:
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PMID: 17083033 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Interleukin (IL)-1 family members are key players in inflammatory processes but have been the subject of few studies of acquired immunodeficiency syndrome (AIDS). To better evaluate the impact of the IL-1 family on AIDS development, we genotyped the IL1 alpha , IL1 beta , IL1Ra, and IL1R1 genes in 245 slow progressor (SP) and 82 rapid progressor (RP) human immunodeficiency virus type 1-seropositive patients as well as in 446 control subjects, all of whom were of white ethnicity. One hundred sixteen frequent polymorphisms were identified, of which 23 were newly characterized by our study. Many putative associations were found between single-nucleotide polymorphism (SNP) or haplotype alleles and the extreme profiles of progression. Most of them corresponded to weak associations (.01<P<.05); however, the SNP IL1Ra_2134 exhibited a consistent association, found at the level of the SNP, haplotypes, and haploblocks, when the SP and control populations were compared (P=.0002). The IL-1-dependent inflammatory response is, thus, likely to play a role in AIDS progression via the regulation of IL-1Ra expression. This association will need to be confirmed in other AIDS cohorts, and experiments will also have to be performed to unravel the biological mechanisms at work. The data presented here will be useful for future genomic studies of the IL-1 family members in other infectious and chronic inflammatory diseases. |
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Authors:
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Herve Do; Alexandre Vasilescu; Wassila Carpentier; Laurence Meyer; Gora Diop; Thomas Hirtzig; Cedric Coulonges; Taoufik Labib; Jean-Louis Spadoni; Amu Therwath; Mark Lathrop; Fumihiko Matsuda; Jean-Francois Zagury |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2006-10-26 |
Journal Detail:
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Title: The Journal of infectious diseases Volume: 194 ISSN: 0022-1899 ISO Abbreviation: J. Infect. Dis. Publication Date: 2006 Dec |
Date Detail:
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Created Date: 2006-11-03 Completed Date: 2007-01-18 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0413675 Medline TA: J Infect Dis Country: United States |
Other Details:
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Languages: eng Pagination: 1492-504 Citation Subset: AIM; IM |
Affiliation:
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Centre National de Genotypage, Evry, Conservatoire National des Arts et Metiers, Paris, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acquired Immunodeficiency Syndrome
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genetics*,
immunology Cohort Studies Disease Progression European Continental Ancestry Group France Genetic Predisposition to Disease* Haplotypes Humans Interleukin 1 Receptor Antagonist Protein / genetics* Interleukin-1alpha / genetics* Interleukin-1beta / genetics* Polymorphism, Genetic* Receptors, Interleukin-1 Type I / genetics* Statistics as Topic |
| Chemical | |
Reg. No./Substance:
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0/IL1R1 protein, human; 0/IL1RN protein, human; 0/Interleukin 1 Receptor Antagonist Protein; 0/Interleukin-1alpha; 0/Interleukin-1beta; 0/Receptors, Interleukin-1 Type I |
| Comments/Corrections | |
Comment In:
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J Infect Dis. 2006 Dec 1;194(11):1475-7
[PMID:
17083030
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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