Document Detail

Exhaled nitric oxide and tracheal endothelin-1 in preterm infants with and without RDS.
MedLine Citation:
PMID:  14520725     Owner:  NLM     Status:  MEDLINE    
We measured exhaled nitric oxide and tracheal aspirate endothelin-1 to determine relationships between these substances and alterations in pulmonary gas exchange during respiratory distress syndrome (RDS) in comparison to those obtained from control preterm infants without RDS. Eight infants with RDS had measurements made at 24 hr and again at 48-72 hr. Eight control infants were studied once at 24-48 hr of life. Exhaled gas was analyzed on-line, and minute excretion of NO (V(NO)) was calculated. ET-1 was determined by immunoassay. Median V(NO) at 24 hr in RDS was 0.405 nl/min/kg (range, 0.30 -0.79), which subsequently declined by 48-72 hr to 0.166 nl/min/kg (P < 0.01). The V(NO) in RDS infants was significantly higher than time-matched V(NO) in controls, with a median of 0.099 nl/min/kg (range, 0.03-0.27; P < 0.001). ET-1 was not correlated with initial V(NO) in the RDS or control patients. In conclusion, in RDS, V(NO) decreases as gas exchange improves. ET-1 is detectable in tracheal aspirate samples in both groups of infants.
Steven L Olsen; Perry L Clark; Donald W Thibeault; Mike Norberg; William E Truog
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pediatric pulmonology     Volume:  36     ISSN:  8755-6863     ISO Abbreviation:  Pediatr. Pulmonol.     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-10-01     Completed Date:  2004-03-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8510590     Medline TA:  Pediatr Pulmonol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  421-6     Citation Subset:  IM    
Copyright Information:
Copyright 2003 Wiley-Liss, Inc.
Section of Neonatology, Department of Pediatrics, Children's Mercy Hospitals and Clinics, University of Missouri-Kansas City School of Medicine, Kansas City, Missouri 64108, USA.
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MeSH Terms
Body Fluids / chemistry*
Breath Tests*
Endothelin-1 / analysis*
Infant, Newborn
Infant, Premature, Diseases / metabolism*,  therapy
Intubation, Intratracheal
Nitric Oxide / analysis*
Pulmonary Surfactants / therapeutic use
Reference Values
Respiratory Distress Syndrome, Newborn / metabolism*,  therapy
Respiratory Function Tests
Grant Support
Reg. No./Substance:
0/Endothelin-1; 0/Pulmonary Surfactants; 10102-43-9/Nitric Oxide

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