Document Detail

Exhaled nitric oxide is reduced in infants with rhinorrhea.
MedLine Citation:
PMID:  15573394     Owner:  NLM     Status:  MEDLINE    
In infants, the effect of colds and other respiratory tract infections (RTI) on exhaled nitric oxide (FE(NO)) is not clear. In this study, we measured FE(NO) in 24 infants (14 boys) who presented with rhinorrhea, with or without cough but not wheeze. Twelve of these infants had a history of recurrent wheeze. Levels were compared with a group of 23 healthy infants (13 boys). Further, 8 infants (5 with a history of recurrent wheeze) with rhinorrhea were tested after symptoms had resolved. Infants with rhinorrhea had significantly lower FE(NO) than the healthy infants (11.9 vs. 23.8 ppb, respectively, P < 0.0007). Levels increased from 7.5 ppb to 34.1 ppb in the 8 infants tested with and without symptoms (P = 0.0002). Infants with rhinorrhea have reduced FE(NO), irrespective of their respiratory history.
Peter J Franklin; Stephen W Turner; Graham L Hall; Alex Moeller; Stephen M Stick
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Pediatric pulmonology     Volume:  39     ISSN:  8755-6863     ISO Abbreviation:  Pediatr. Pulmonol.     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-01-05     Completed Date:  2005-05-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8510590     Medline TA:  Pediatr Pulmonol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  117-9     Citation Subset:  IM    
School of Paediatrics and Child Health, University of Western Australia, Perth, Western Australia, Australia.
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MeSH Terms
Airway Resistance / physiology
Biological Markers
Breath Tests
Chronic Disease
Cough / metabolism,  physiopathology
Forced Expiratory Volume / physiology
Nitric Oxide / analysis*
Regression Analysis
Respiratory Sounds / physiology
Rhinitis / metabolism*,  physiopathology
Reg. No./Substance:
0/Biological Markers; 10102-43-9/Nitric Oxide

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