| Exhaled nitric oxide, lung function, and exacerbations in wheezy infants and toddlers. | |
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MedLine Citation:
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PMID: 20462633 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: There are limited data assessing the relationship between fraction of exhaled nitric oxide and lung function or exacerbations in infants with recurrent wheezing. OBJECTIVES: In a longitudinal pilot study of children less than 2 years old, we assessed whether baseline fraction of exhaled nitric oxide was associated with lung function, bronchodilator responsiveness, changes in lung function, or subsequent exacerbations of wheezing. METHODS: Forced expiratory flows and volumes using the raised-volume rapid thoracic compression method were measured in 44 infants and toddlers (mean age, 15.7 months) with recurrent wheezing. Single-breath exhaled nitric oxide (SB-eNO) was measured at 50 mL/s. Lung function was again measured 6 months after enrollment. RESULTS: At enrollment, forced expiratory volume in 0.5 seconds (FEV(0.5)), forced expiratory flow at 25% to 75% of expiration (FEF(25-75)), and forced expiratory flow at 75% of expiration (FEF(75)) z scores for the cohort were significantly less than zero. There was no correlation between enrollment SB-eNO levels and enrollment lung function measures. SB-eNO levels were higher in infants with bronchodilator responsiveness (46.1 vs 23.6 ppb, P < .001) and was associated with a decrease in FEV(0.5) (r = -0.54, P = .001), FEF(25-75) (r = -0.6, P < .001), and FEF(75) (r = -0.55, P = .001) over 6 months. A 10-ppb increase in SB-eNO level was associated with a 0.4-point z score decrease in FEV(0.5), a 0.4-point z score decrease in FEF(25-75), and a 0.42-point z score decrease in FEF(75). SB-eNO level was superior to lung function and bronchodilator responsiveness in predicting subsequent wheezing treated with systemic steroids. CONCLUSIONS: SB-eNO level might predict changes in lung function and risk of future wheezing and holds promise as a biomarker to predict asthma in wheezy infants and toddlers. |
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Authors:
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Jason S Debley; David C Stamey; Elizabeth S Cochrane; Kim L Gama; Gregory J Redding |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-05-11 |
Journal Detail:
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Title: The Journal of allergy and clinical immunology Volume: 125 ISSN: 1097-6825 ISO Abbreviation: J. Allergy Clin. Immunol. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-01 Completed Date: 2010-08-24 Revised Date: 2013-03-05 |
Medline Journal Info:
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Nlm Unique ID: 1275002 Medline TA: J Allergy Clin Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 1228-1234.e13 Citation Subset: AIM; IM |
Copyright Information:
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Copyright (c) 2010 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved. |
Affiliation:
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Department of Pediatrics, Division of Pulmonary Medicine, Seattle Children's Hospital, University of Washington, Seattle, WA, USA. jason.debley@seattlechildrens.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Asthma
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diagnosis*,
physiopathology Breath Tests* / instrumentation, methods Bronchodilator Agents / administration & dosage Female Humans Infant Infant, Newborn Male Nitric Oxide / analysis* Pilot Projects Predictive Value of Tests Respiratory Function Tests Respiratory Sounds Sensitivity and Specificity |
| Grant Support | |
ID/Acronym/Agency:
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I ULI RR025014-01/RR/NCRR NIH HHS; K23 HL077626/HL/NHLBI NIH HHS; K23 HL077626-01A1/HL/NHLBI NIH HHS; K23HL077626/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Bronchodilator Agents; 10102-43-9/Nitric Oxide |
| Comments/Corrections | |
Comment In:
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J Allergy Clin Immunol. 2010 Jun;125(6):1235-6
[PMID:
20513520
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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