Document Detail

Exhaled nitric oxide level during and after heavy exercise in athletes with exercise-induced hypoxaemia.
MedLine Citation:
PMID:  12111248     Owner:  NLM     Status:  MEDLINE    
Endogenous nitric oxide (NO) is an important mediator of vasodilatation, bronchodilatation and lung inflammation. We hypothesised that the exhaled NO level may be modified in some endurance-trained athletes during and after intense exercise. Nine athletes with exercise-induced hypoxaemia (EIH), 12 athletes without EIH and 10 untrained subjects exercised for 15 min at 90% maximal oxygen consumption (VO(2)max). Exhaled NO was measured during exercise, and after 1 h and 22 h of recovery. Exhaled NO concentration ( C(NO)) decreased significantly during exercise in all subjects and returned to basal values after 1 h of recovery with no further modification. Exhaled NO output (V(NO)) rose significantly during exercise, rapidly dropped down following exercise and was similar to resting values after 1 h and 22 h of recovery. The results also showed that C(NO) and V(NO) were significantly lower in the athletes with EIH in comparison with the untrained subjects (V(NO) was 5.32 +/- 0.77 nmol/min versus 3.61 +/- 0.72 nmol/min at rest, 18.52 +/- 1.50 nmol/min versus 15.00 +/- 2.06 nmol/min during heavy exercise, and 5.52 +/- 1.04 nmol/min versus 3.79 +/- 0.76 nmol/min after 22 h recovery, in untrained subjects and EIH athletes, respectively). These findings do not confirm the hypothesis of pulmonary inflammation associated with EIH. However, potential NO epithelial down-regulation may occur and contribute to the development of gas exchange abnormality in some endurance-trained athletes.
Pascale Kippelen; Corinne Caillaud; Emmanuelle Robert; Kaouthar Masmoudi; Christian Préfaut
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Publication Detail:
Type:  Journal Article     Date:  2002-03-15
Journal Detail:
Title:  Pflügers Archiv : European journal of physiology     Volume:  444     ISSN:  0031-6768     ISO Abbreviation:  Pflugers Arch.     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-07-11     Completed Date:  2003-02-12     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0154720     Medline TA:  Pflugers Arch     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  397-404     Citation Subset:  IM    
Laboratoire de Physiologie des Interactions, Service de Physiologie Clinique, Hôpital Arnaud de Villeneuve, 34295 Montpellier cedex 5, France.
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MeSH Terms
Anoxia / metabolism*,  physiopathology*
Body Weight
Exercise Test
Nitric Oxide / metabolism*
Oxygen / blood
Oxygen Consumption / physiology
Physical Endurance / physiology*
Physical Exertion / physiology*
Pneumonia / physiopathology
Pulmonary Gas Exchange
Respiratory Mechanics
Reg. No./Substance:
10102-43-9/Nitric Oxide; 7782-44-7/Oxygen

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