| Exhaled nitric oxide decreases during exercise in non-asthmatic children. | |
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MedLine Citation:
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PMID: 22521142 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Introduction: Exhaled nitric oxide (FE(NO) ) measurements are recommended to be performed before spirometry and exercise challenge tests because forced breathing might influence FE(NO ) values. Information on the effect of exercise on FE(NO) is lacking in non-asthmatic children. Aim: To investigate the effect on FE(NO) of a standardized exercise challenge test on a treadmill in non-asthmatic children with and without allergic rhinoconjunctivitis (AR) symptoms. Methods: From the case-control study "Asthma and allergy among schoolchildren in Nordland", 330 non-asthmatic pupils age 8-16 years were enrolled. FE(NO) was measured at baseline and at 1 and 30 min after exercise challenge test by the single breath technique with EcoMedics Exhalazer®. Results: Pair-wise comparison of FE(NO) from baseline demonstrated a highly significant reduction in FE(NO) post exercise for all children at 1 min (27.4%) and at 30 min (16.1%) (p<0.001). The AR group had a significantly higher decline in FE(NO ) value at 1 min post exercise compared to the non-AR group, 4.2 ppb versus 2.6 ppb (p<0.001). Decline in FE(NO) immediately post exercise was more significant if baseline FE(NO) was ≥ 20 ppb; mean reduction 9.9 (95% CI: 8.7-11.4) ppb. Conclusion: FE(NO ) is reduced by 27.4% immediately after a standardized treadmill exercise test in non-asthmatic children. Pupils reporting AR symptoms demonstrate a larger decline in FE(NO ) value at 1 min post exercise compared to pupils without AR symptoms. These findings confirm that children should refrain from physical activity before FE(NO ) measurement. © 2012 Blackwell Publishing Ltd. |
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Authors:
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Bjørg Evjenth; Tonje E Hansen; Jan Holt |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-4-23 |
Journal Detail:
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Title: The clinical respiratory journal Volume: - ISSN: 1752-699X ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-4-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101315570 Medline TA: Clin Respir J Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 Blackwell Publishing Ltd. |
Affiliation:
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Department of Pediatrics, Division of Pediatrics, Obstetrics and Womens's Health, Nordland Hospital, Bodø, Norway Institute of Clinical Medicine, University of Tromsø. Tromsø, Norway. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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