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Exhaled nitric oxide decreases during exercise in non-asthmatic children.
MedLine Citation:
PMID:  22521142     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Introduction:  Exhaled nitric oxide (FE(NO) ) measurements are recommended to be performed before spirometry and exercise challenge tests because forced breathing might influence FE(NO ) values. Information on the effect of exercise on FE(NO) is lacking in non-asthmatic children. Aim:   To investigate the effect on FE(NO) of a standardized exercise challenge test on a treadmill in non-asthmatic children with and without allergic rhinoconjunctivitis (AR) symptoms. Methods:  From the case-control study "Asthma and allergy among schoolchildren in Nordland", 330 non-asthmatic pupils age 8-16 years were enrolled. FE(NO) was measured at baseline and at 1 and 30 min after exercise challenge test by the single breath technique with EcoMedics Exhalazer®. Results:  Pair-wise comparison of FE(NO) from baseline demonstrated a highly significant reduction in FE(NO) post exercise for all children at 1 min (27.4%) and at 30 min (16.1%) (p<0.001). The AR group had a significantly higher decline in FE(NO ) value at 1 min post exercise compared to the non-AR group, 4.2 ppb versus 2.6 ppb (p<0.001). Decline in FE(NO) immediately post exercise was more significant if baseline FE(NO) was ≥ 20 ppb; mean reduction 9.9 (95% CI: 8.7-11.4) ppb. Conclusion:  FE(NO ) is reduced by 27.4% immediately after a standardized treadmill exercise test in non-asthmatic children. Pupils reporting AR symptoms demonstrate a larger decline in FE(NO ) value at 1 min post exercise compared to pupils without AR symptoms. These findings confirm that children should refrain from physical activity before FE(NO ) measurement. © 2012 Blackwell Publishing Ltd.
Authors:
Bjørg Evjenth; Tonje E Hansen; Jan Holt
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-23
Journal Detail:
Title:  The clinical respiratory journal     Volume:  -     ISSN:  1752-699X     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101315570     Medline TA:  Clin Respir J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 Blackwell Publishing Ltd.
Affiliation:
Department of Pediatrics, Division of Pediatrics, Obstetrics and Womens's Health, Nordland Hospital, Bodø, Norway Institute of Clinical Medicine, University of Tromsø. Tromsø, Norway.
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