Document Detail

Exhaled nitric oxide and airway caliber during exercise-induced bronchoconstriction.
MedLine Citation:
PMID:  17120347     Owner:  NLM     Status:  MEDLINE    
Data on the relationship between exercise-induced bronchoconstriction (EIB) and exhaled nitric oxide (NO) in adult patients with asthma are controversial. It is unclear whether endogenous NO may act as either a protective or stimulatory factor in the airway response to exercise or whether changes in exhaled NO simply reflect acute narrowing of the airway. The aim of this study was to assess the changes in the fraction of exhaled nitric oxide (FE(NO)) before and after exercise challenge in patients with asthma and to analyze the relationship between FE(NO) and airway obstruction. Twenty-five non-smoking, steroid-naïve, atopic, adult patients with mild persistent asthma and 12 non-smoking, nonatopic, healthy subjects (control group) performed an exercise challenge on a cycloergometer, with monitored ventilation. FEV1 and FE(NO) were measured at baseline and 1, 5, 10, 15 and 20 minutes after the exercise challenge. Eleven of the asthmatic patients had exercise-induced bronchoconstriction (EIB group) and the remaining 14 did not (non-EIB group). Baseline FE(NO) was higher in the EIB and non-EIB asthmatic groups than in the control group. In the EIB group, FE(NO) was significantly lower 5, 10 and 15 minutes after exercise, and the changes in FE(NO) correlated with variation in FEV1 10 and 15 min after exercise. A significant correlation between baseline FE(NO) and maximal post-exercise decrease in FEV1 was found in asthmatic patients (EIB group). In conclusion, exhaled nitric oxide levels transiently decrease during exercise-induced bronchoconstriction in adult patients with asthma. Baseline FE(NO) might predict the airway obstruction resulting after exercise.
F García-Río; M Ramírez; O Mediano; V Lores; B Rojo; C Villasante; J Villamor
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of sports medicine     Volume:  27     ISSN:  0172-4622     ISO Abbreviation:  Int J Sports Med     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-11-21     Completed Date:  2007-03-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8008349     Medline TA:  Int J Sports Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  905-10     Citation Subset:  IM    
Servicio de Neumología, Hospital Universitario La Paz, Madrid, Spain.
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MeSH Terms
Airway Obstruction / physiopathology
Asthma, Exercise-Induced / physiopathology*
Breath Tests / methods
Epidemiologic Methods
Exercise Test / methods
Exhalation / physiology*
Middle Aged
Nitric Oxide / analysis*
Pulmonary Ventilation / physiology*
Reg. No./Substance:
10102-43-9/Nitric Oxide

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