Document Detail


Exhaled metallic elements and serum pneumoproteins in asymptomatic smokers and patients with COPD or asthma.
MedLine Citation:
PMID:  16685021     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
STUDY OBJECTIVES: The aim of this study was to characterize the elemental composition of exhaled breath condensate (EBC) in order to identify new biomarkers of exposure and susceptibility in COPD patients. Serum pneumoproteins were used as lung-specific biomarkers of effect.
DESIGN: EBC was obtained from 50 healthy subjects, 30 healthy smokers, 30 asthmatics, and 50 patients with stable COPD, and was collected by cooling exhaled air. Trace elements and toxic metals in the samples were measured by means of inductively coupled plasma-mass spectrometry and electrothermal atomic absorption spectroscopy. The serum pneumoproteins were immunoassayed.
RESULTS: The EBC of COPD subjects had higher levels of such toxic elements as lead, cadmium, and aluminum, and lower levels of iron and copper, than that of the nonsmoking control subjects. There were no between-group differences in surfactant protein (SP)-A and SP-B levels. Clara-cell protein and SP-D levels were negatively and positively influenced, respectively, by tobacco smoke.
CONCLUSIONS: Our results show that toxic metals and transition elements are detectable in the EBC of studied subjects. We propose new biomarkers of exposure as a means of assessing the target tissue dose of carcinogenic and pneumotoxic substances from tobacco smoke or polluted workplaces, and the use of the transition elements involved in redox systems of oxidative stress as disease biomarkers associated with effect or susceptibility. Together with biomarkers of effect, such as serum pneumoproteins, the elemental composition of EBC may be clinically useful in distinguishing similar diseases.
Authors:
Antonio Mutti; Massimo Corradi; Matteo Goldoni; Maria Vittoria Vettori; Alfred Bernard; Pietro Apostoli
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Chest     Volume:  129     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-05-10     Completed Date:  2006-05-30     Revised Date:  2013-06-07    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1288-97     Citation Subset:  AIM; IM    
Affiliation:
Laboratory of Industrial Toxicology, Department of Clinical Medicine, Nephrology, and Health Sciences, University of Parma, Via Gramsci 14, 43100 Parma, Italy. antonio.mutti@unipr.it
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Asthma / metabolism*
Biological Markers / analysis,  metabolism
Breath Tests
Enzyme-Linked Immunosorbent Assay
Female
Humans
Male
Middle Aged
Prognosis
Pulmonary Disease, Chronic Obstructive / metabolism*
Pulmonary Surfactant-Associated Protein A / blood*
Pulmonary Surfactant-Associated Protein B / blood*
Pulmonary Surfactant-Associated Protein D / blood
Smoking / metabolism*
Spectrum Analysis
Trace Elements / analysis*
Uteroglobin / blood
Grant Support
ID/Acronym/Agency:
R01 HL072323-04/HL/NHLBI NIH HHS; R01 HL72323/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Pulmonary Surfactant-Associated Protein A; 0/Pulmonary Surfactant-Associated Protein B; 0/Pulmonary Surfactant-Associated Protein D; 0/SCGB1A1 protein, human; 0/Trace Elements; 9060-09-7/Uteroglobin
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