| Exhaled breath condensate levels of eotaxin and macrophage-derived chemokine in stable adult asthma patients. | |
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MedLine Citation:
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PMID: 16393265 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Asthma is associated with esoinophilic airway inflammation and overproduction of T-helper type 2 (Th2) lymphocyte-related cytokines. OBJECTIVE: This study assessed the eosinophil chemoattractant eotaxin and Th2-specific macrophage-derived chemokine (MDC) in the adult asthmatic airway. Eotaxin and MDC levels were determined in exhaled breath condensate (EBC) obtained from adult patients with asthma. METHODS: Fifty-four asthmatics (20 male, mean (SD) age 40 (12) years and percentage predicted forced expiratory volume in 1 s (FEV(1)) 81.7 (20.8)) and 20 age- and sex-matched controls were studied. EBC was collected using EcoScreen by 10 min of tidal breathing with a nose clip. Concentrations of eotaxin and MDC were measured by ELISA. RESULTS: Asthma patients on inhaled corticosteroid (ICS) had a higher median interquartile range (IQR) level of eotaxin than the steroid-naïve asthmatics (18.5 (17.7-20.1) vs. 17.9 (17.0-18.6) pg/mL, P=0.02) and controls (18.5 (17.7-20.1) pg/mL vs 17.4 (16.3-18.0) pg/mL, P=0.001). Eotaxin level in EBC had a significant negative correlation with the FEV(1)/forced vital capacity ratio (r=-0.43, P=0.03) in steroid-naïve asthmatics. EBC MDC level was higher in subjects on ICS than the steroid naïve asthmatics (120 (118-125) vs. 117 (116-119) pg/mL, P=0.01) and the controls (120 (118-125) vs. 117 (116-120) pg/mL, P=0.02). CONCLUSIONS: Eotaxin and MDC could be measured in EBC of adults with asthma. EBC eotaxin and MDC levels were higher in asthmatics on ICS than the steroid-naïve asthmatics or controls. Exhaled chemokines may be potential non-invasive markers for assessing airway inflammation in asthmatics. |
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Authors:
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F W S Ko; C Y K Lau; T F Leung; G W K Wong; C W K Lam; C K W Lai; D S C Hui |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology Volume: 36 ISSN: 0954-7894 ISO Abbreviation: Clin. Exp. Allergy Publication Date: 2006 Jan |
Date Detail:
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Created Date: 2006-01-05 Completed Date: 2006-05-03 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8906443 Medline TA: Clin Exp Allergy Country: England |
Other Details:
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Languages: eng Pagination: 44-51 Citation Subset: IM |
Affiliation:
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Departments of Medicine and Therapeutics, Paediatrics and Chemical Pathology, The Chinese University of Hong Kong, Hong Kong, China. fannyko@cuhk.edu.hk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Inhalation Adrenal Cortex Hormones / therapeutic use Adult Asthma / drug therapy, immunology* Biological Markers / analysis Breath Tests Case-Control Studies Chemokine CCL11 Chemokine CCL22 Chemokines, CC / analysis* Cross-Sectional Studies Eosinophils / immunology Female Humans Immunoenzyme Techniques Lung / immunology* Male Skin Tests Statistics, Nonparametric |
| Chemical | |
Reg. No./Substance:
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0/Adrenal Cortex Hormones; 0/Biological Markers; 0/CCL11 protein, human; 0/CCL22 protein, human; 0/Chemokine CCL11; 0/Chemokine CCL22; 0/Chemokines, CC |
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