| Exhaled breath condensate cysteinyl leukotrienes are increased in children with exercise-induced bronchoconstriction. | |
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MedLine Citation:
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PMID: 15805996 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: It is recognized that airway inflammation has a central role in the pathogenesis of asthma, but how it relates to exercise-induced bronchoconstriction (EIB) is not completely understood. OBJECTIVE: The aim of our study was to investigate the relationship between EIB and baseline concentrations of cysteinyl leukotrienes (Cys-LTs) and other inflammatory markers in exhaled breath condensate (EBC). METHODS: EBC was collected, and the fraction of exhaled nitric oxide (FE NO ) was measured in a group of 19 asthmatic children, after which they performed a treadmill exercise test. Fourteen healthy children were enrolled as control subjects. RESULTS: The asthmatic children were divided into the EIB group (decrease in FEV 1 , > or =12%) and the non-EIB group. The EBC was analyzed for the presence of Cys-LTs, leukotriene B 4 , and ammonia. Asthmatic patients with EIB (mean FEV 1 decrease, 23% +/- 3%) had higher Cys-LT concentrations than either asthmatic patients without EIB or control subjects (42.2 pg/mL [median] vs 11.7 pg/mL and 5.8 pg/mL; P < .05 and P < .001, respectively). Ammonia concentrations were lower in both the EIB and non-EIB groups than in control subjects (253.2 microM and 334.6 microM vs 798.4 microM; P < .01 and P < .05, respectively). No difference in EBC leukotriene B 4 levels was found among the 3 groups. Both asthmatic groups had higher FE NO levels than control subjects ( P < .001). EBC Cys-LT ( P < .01; r = 0.7) and FE NO ( P < .05; r = 0.5) values both correlated significantly with the postexercise FEV 1 decrease. CONCLUSION: this study shows that EBC Cys-LT values are higher in asthmatic children with EIB and correlate with the decrease in FEV 1 after exercise. These findings suggest that the pathways of both Cys-LT and nitric oxide are involved in the pathogenesis of EIB. |
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Authors:
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Silvia Carraro; Massimo Corradi; Stefania Zanconato; Rossella Alinovi; Maria Francesca Pasquale; Franco Zacchello; Eugenio Baraldi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of allergy and clinical immunology Volume: 115 ISSN: 0091-6749 ISO Abbreviation: J. Allergy Clin. Immunol. Publication Date: 2005 Apr |
Date Detail:
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Created Date: 2005-04-04 Completed Date: 2005-05-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1275002 Medline TA: J Allergy Clin Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 764-70 Citation Subset: AIM; IM |
Affiliation:
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Department of Pediatrics, University of Padua, Via Giustiniani 3, 35128 Padua, Italy. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetates
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therapeutic use Adolescent Ammonia / analysis, metabolism Asthma, Exercise-Induced / drug therapy, physiopathology* Biological Markers / analysis* Breath Tests Bronchoconstriction / drug effects Child Cysteine / analysis*, drug effects, metabolism Exhalation Forced Expiratory Volume Humans Leukotriene Antagonists / therapeutic use Leukotriene B4 / analysis, metabolism Leukotrienes / analysis*, metabolism Nitric Oxide / analysis, metabolism Quinolines / therapeutic use Respiratory Function Tests |
| Chemical | |
Reg. No./Substance:
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0/Acetates; 0/Biological Markers; 0/Leukotriene Antagonists; 0/Leukotrienes; 0/Quinolines; 0/cysteinyl-leukotriene; 10102-43-9/Nitric Oxide; 158966-92-8/montelukast; 52-90-4/Cysteine; 71160-24-2/Leukotriene B4; 7664-41-7/Ammonia |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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