Document Detail


Exhaled breath condensate cysteinyl leukotrienes are increased in children with exercise-induced bronchoconstriction.
MedLine Citation:
PMID:  15805996     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: It is recognized that airway inflammation has a central role in the pathogenesis of asthma, but how it relates to exercise-induced bronchoconstriction (EIB) is not completely understood. OBJECTIVE: The aim of our study was to investigate the relationship between EIB and baseline concentrations of cysteinyl leukotrienes (Cys-LTs) and other inflammatory markers in exhaled breath condensate (EBC). METHODS: EBC was collected, and the fraction of exhaled nitric oxide (FE NO ) was measured in a group of 19 asthmatic children, after which they performed a treadmill exercise test. Fourteen healthy children were enrolled as control subjects. RESULTS: The asthmatic children were divided into the EIB group (decrease in FEV 1 , > or =12%) and the non-EIB group. The EBC was analyzed for the presence of Cys-LTs, leukotriene B 4 , and ammonia. Asthmatic patients with EIB (mean FEV 1 decrease, 23% +/- 3%) had higher Cys-LT concentrations than either asthmatic patients without EIB or control subjects (42.2 pg/mL [median] vs 11.7 pg/mL and 5.8 pg/mL; P < .05 and P < .001, respectively). Ammonia concentrations were lower in both the EIB and non-EIB groups than in control subjects (253.2 microM and 334.6 microM vs 798.4 microM; P < .01 and P < .05, respectively). No difference in EBC leukotriene B 4 levels was found among the 3 groups. Both asthmatic groups had higher FE NO levels than control subjects ( P < .001). EBC Cys-LT ( P < .01; r = 0.7) and FE NO ( P < .05; r = 0.5) values both correlated significantly with the postexercise FEV 1 decrease. CONCLUSION: this study shows that EBC Cys-LT values are higher in asthmatic children with EIB and correlate with the decrease in FEV 1 after exercise. These findings suggest that the pathways of both Cys-LT and nitric oxide are involved in the pathogenesis of EIB.
Authors:
Silvia Carraro; Massimo Corradi; Stefania Zanconato; Rossella Alinovi; Maria Francesca Pasquale; Franco Zacchello; Eugenio Baraldi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  115     ISSN:  0091-6749     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-04-04     Completed Date:  2005-05-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  764-70     Citation Subset:  AIM; IM    
Affiliation:
Department of Pediatrics, University of Padua, Via Giustiniani 3, 35128 Padua, Italy.
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MeSH Terms
Descriptor/Qualifier:
Acetates / therapeutic use
Adolescent
Ammonia / analysis,  metabolism
Asthma, Exercise-Induced / drug therapy,  physiopathology*
Biological Markers / analysis*
Breath Tests
Bronchoconstriction / drug effects
Child
Cysteine / analysis*,  drug effects,  metabolism
Exhalation
Forced Expiratory Volume
Humans
Leukotriene Antagonists / therapeutic use
Leukotriene B4 / analysis,  metabolism
Leukotrienes / analysis*,  metabolism
Nitric Oxide / analysis,  metabolism
Quinolines / therapeutic use
Respiratory Function Tests
Chemical
Reg. No./Substance:
0/Acetates; 0/Biological Markers; 0/Leukotriene Antagonists; 0/Leukotrienes; 0/Quinolines; 0/cysteinyl-leukotriene; 10102-43-9/Nitric Oxide; 158966-92-8/montelukast; 52-90-4/Cysteine; 71160-24-2/Leukotriene B4; 7664-41-7/Ammonia

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