| Exertional dyspnea and ventilation in hyperthyroidism. | |
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MedLine Citation:
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PMID: 1582283 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dyspnea is recognized to be an important feature in patients with hyperthyroidism at rest and during exercise. However, its etiology is not well-understood. Since dyspnea is thought to be related to the perception of excessive ventilatory effort, we explored the possibility that dyspnea in these patients might be related to an inappropriate ventilatory response to the increased metabolic rate. We studied 11 hyperthyroid patients and 11 age- and sex-matched controls, performing spirometry, lung volumes, mouth pressure measurements, and incremental exercise test. Central drive was estimated by measuring P0.1 and sensation of dyspnea by the Borg scale. We found that hyperthyroid patients (1) have higher ventilation than normal subjects during exercise even when corrected for VCO2 levels; (2) this increased ventilation is secondary to increased central drive which is correlated to the T3ria level (r = 0.85, p less than 0.01); (3) hyperthyroid patients are more dyspneic than controls; and (4) the increased drive can be normalized by beta-blockade. We conclude that the main ventilatory abnormality in hyperthyroid patients is an inappropriate increase in respiratory drive, possibly secondary to increased adrenergic stimulation. |
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Authors:
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D Small; W Gibbons; R D Levy; P de Lucas; W Gregory; M G Cosio |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Chest Volume: 101 ISSN: 0012-3692 ISO Abbreviation: Chest Publication Date: 1992 May |
Date Detail:
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Created Date: 1992-06-12 Completed Date: 1992-06-12 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0231335 Medline TA: Chest Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1268-73 Citation Subset: AIM; IM |
Affiliation:
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Desmond N. Stoker Pulmonary Laboratory, Royal Victoria Hospital, McGill University, Montreal (Quebec), Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Carbon Dioxide / physiology Dyspnea / etiology*, physiopathology Female Forced Expiratory Volume Heart Rate Humans Hyperthyroidism / complications*, physiopathology Male Physical Exertion* Pulmonary Ventilation Respiratory Mechanics* Vital Capacity |
| Chemical | |
Reg. No./Substance:
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124-38-9/Carbon Dioxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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