| Exertional dyspnea-related acidotic and sympathetic responses in patients with sequelae of pulmonary tuberculosis. | |
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MedLine Citation:
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PMID: 20087706 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The objective of this study was to investigate whether exertional dyspnea correlates with exercise responses, especially arterial blood pH and plasma norepinephrine (NE) changes, in patients with sequelae of tuberculosis (TBsq). Cardiopulmonary exercise testings were performed in 49 TBsq patients and 9 controls. Each group had a break point in the dyspnea, plasma lactate, and plasma NE changes during exercise, all of which occurred at a similar exercise point. In TBsq patients in both exercise phases before and after the dyspnea break point, the dyspnea-slope (DeltaBorg scale/Deltaminute ventilation) correlated with the pH-slope (DeltapH/Deltaoxygen uptake) (r = -0.616, p < 0.0001; r = -0.629, p < 0.0001, respectively, before and after the break point) and with the NE-slope (DeltaNE/Deltaoxygen uptake) (r = 0.443, p = 0.0012; r = 0.643, p < 0.0001, respectively, before and after the break point). In TBsq patients during exercise, increases in circulating NE levels and exertional acidosis were correlated with exertional dyspnea. |
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Authors:
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Keisuke Miki; Ryoji Maekura; Toru Hiraga; Hisako Hashimoto; Seigo Kitada; Mari Miki; Kenji Yoshimura; Yoshitaka Tateishi; Teppei Sugano; Masaharu Motone |
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Publication Detail:
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Type: Journal Article Date: 2010-01-20 |
Journal Detail:
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Title: The journal of physiological sciences : JPS Volume: 60 ISSN: 1880-6562 ISO Abbreviation: J Physiol Sci Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-12 Completed Date: 2010-07-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101262417 Medline TA: J Physiol Sci Country: Japan |
Other Details:
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Languages: eng Pagination: 187-93 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, National Hospital Organization Toneyama National Hospital, 5-1-1 Toneyama, Toyonaka, Osaka, Japan. mikisuke@toneyama.go.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acidosis
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blood* Aged Dyspnea / physiopathology* Exercise / physiology* Exercise Test / methods Female Humans Hydrogen-Ion Concentration Lactates / blood Male Middle Aged Norepinephrine / blood Tuberculosis, Pulmonary / complications* |
| Chemical | |
Reg. No./Substance:
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0/Lactates; 51-41-2/Norepinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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