Document Detail

Exertional collapse and sudden death associated with sickle cell trait.
MedLine Citation:
PMID:  8677839     Owner:  NLM     Status:  MEDLINE    
Although rare, exertional collapse and sudden death are the most serious potential complications of sickle cell trait. Studies suggest that this condition may occur in susceptible persons when poor physical conditioning, dehydration, heat stress or hypoxic states precipitate sickling of the abnormal erythrocytes. Sickling leads to endothelial damage, which can cause vasoconstriction, disseminated intravascular coagulation and local tissue damage. Cardiac effects include acute ischemia and arrhythmias. Muscle damage results in acute compartment syndromes and release of myoglobin into the circulation. Acute renal failure is possible. Diagnosis is based on a high index of suspicion, and characteristic presentation and laboratory findings, including myoglobinuria, hyperkalemia, hypocalcemia, hyperphosphatemia and elevated creatine kinase levels. The differential diagnosis includes pulmonary embolism, acute cardiac events, anaphylaxis and heat stroke. Management is based on stabilization, rehydration, and the treatment and prevention of complications.
K K Kerle; K D Nishimura
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  American family physician     Volume:  54     ISSN:  0002-838X     ISO Abbreviation:  Am Fam Physician     Publication Date:  1996 Jul 
Date Detail:
Created Date:  1996-08-14     Completed Date:  1996-08-14     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  1272646     Medline TA:  Am Fam Physician     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  237-40     Citation Subset:  AIM; IM    
Martin Army Community Hospital, Fort Benning, Georgia, USA.
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MeSH Terms
Death, Sudden / epidemiology,  etiology*
Physical Exertion*
Sickle Cell Trait / complications*,  epidemiology,  physiopathology
United States / epidemiology
Comment In:
Am Fam Physician. 1997 Feb 15;55(3):784   [PMID:  9048499 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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