| Exertional collapse and sudden death associated with sickle cell trait. | |
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MedLine Citation:
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PMID: 8677839 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although rare, exertional collapse and sudden death are the most serious potential complications of sickle cell trait. Studies suggest that this condition may occur in susceptible persons when poor physical conditioning, dehydration, heat stress or hypoxic states precipitate sickling of the abnormal erythrocytes. Sickling leads to endothelial damage, which can cause vasoconstriction, disseminated intravascular coagulation and local tissue damage. Cardiac effects include acute ischemia and arrhythmias. Muscle damage results in acute compartment syndromes and release of myoglobin into the circulation. Acute renal failure is possible. Diagnosis is based on a high index of suspicion, and characteristic presentation and laboratory findings, including myoglobinuria, hyperkalemia, hypocalcemia, hyperphosphatemia and elevated creatine kinase levels. The differential diagnosis includes pulmonary embolism, acute cardiac events, anaphylaxis and heat stroke. Management is based on stabilization, rehydration, and the treatment and prevention of complications. |
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Authors:
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K K Kerle; K D Nishimura |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: American family physician Volume: 54 ISSN: 0002-838X ISO Abbreviation: Am Fam Physician Publication Date: 1996 Jul |
Date Detail:
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Created Date: 1996-08-14 Completed Date: 1996-08-14 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 1272646 Medline TA: Am Fam Physician Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 237-40 Citation Subset: AIM; IM |
Affiliation:
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Martin Army Community Hospital, Fort Benning, Georgia, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Death, Sudden
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epidemiology,
etiology* Humans Physical Exertion* Sickle Cell Trait / complications*, epidemiology, physiopathology United States / epidemiology |
| Comments/Corrections | |
Comment In:
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Am Fam Physician. 1997 Feb 15;55(3):784
[PMID:
9048499
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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