| Exercise with hypoventilation induces lower muscle oxygenation and higher blood lactate concentration: role of hypoxia and hypercapnia. | |
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MedLine Citation:
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PMID: 20503056 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Eight men performed three series of 5-min exercise on a cycle ergometer at 65% of normoxic maximal O(2) consumption in four conditions: (1) voluntary hypoventilation (VH) in normoxia (VH(0.21)), (2) VH in hyperoxia (inducing hypercapnia) (inspired oxygen fraction [F(I)O(2)] = 0.29; VH(0.29)), (3) normal breathing (NB) in hypoxia (F(I)O(2) = 0.157; NB(0.157)), (4) NB in normoxia (NB(0.21)). Using near-infrared spectroscopy, changes in concentration of oxy-(Delta[O(2)Hb]) and deoxyhemoglobin (Delta[HHb]) were measured in the vastus lateralis muscle. Delta[O(2)Hb - HHb] and Delta[O(2)Hb + HHb] were calculated and used as oxygenation index and change in regional blood volume, respectively. Earlobe blood samples were taken throughout the exercise. Both VH(0.21) and NB(0.157) induced a severe and similar hypoxemia (arterial oxygen saturation [SaO(2)] < 88%) whereas SaO(2) remained above 94% and was not different between VH(0.29) and NB(0.21). Arterialized O(2) and CO(2) pressures as well as P50 were higher and pH lower in VH(0.21) than in NB(0.157), and in VH(0.29) than in NB(0.21). Delta[O(2)Hb] and Delta[O(2)Hb - HHb] were lower and Delta[HHb] higher at the end of each series in both VH(0.21) and NB(0.157) than in NB(0.21) and VH(0.29). There was no difference in Delta[O(2)Hb + HHb] between testing conditions. [La] in VH(0.21) was greater than both in NB(0.21) and VH(0.29) but not different from NB(0.157). This study demonstrated that exercise with VH induced a lower tissue oxygenation and a higher [La] than exercise with NB. This was caused by a severe arterial O(2) desaturation induced by both hypoxic and hypercapnic effects. |
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Authors:
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Xavier Woorons; Nicolas Bourdillon; Henri Vandewalle; Christine Lamberto; Pascal Mollard; Jean-Paul Richalet; Aurélien Pichon |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial Date: 2010-05-26 |
Journal Detail:
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Title: European journal of applied physiology Volume: 110 ISSN: 1439-6327 ISO Abbreviation: Eur. J. Appl. Physiol. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-27 Completed Date: 2010-12-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100954790 Medline TA: Eur J Appl Physiol Country: Germany |
Other Details:
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Languages: eng Pagination: 367-77 Citation Subset: IM |
Affiliation:
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Université Paris 13, Laboratoire Réponses cellulaires et fonctionnelles à l'hypoxie, EA 2363 UFR-SMBH, Bobigny, France. xwoorons@laposte.net |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anoxia / blood*, physiopathology Bicycling Carbon Dioxide / blood Ear / blood supply Exercise* Hemoglobins / metabolism Humans Hypercapnia / blood*, physiopathology Hypoventilation / blood*, physiopathology Lactic Acid / blood* Male Muscle Contraction* Muscle, Skeletal / blood supply, metabolism* Oximetry Oxygen / blood* Oxygen Consumption* Oxyhemoglobins / metabolism Respiratory Mechanics Spectroscopy, Near-Infrared Time Factors Up-Regulation Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Hemoglobins; 0/Oxyhemoglobins; 124-38-9/Carbon Dioxide; 50-21-5/Lactic Acid; 7782-44-7/Oxygen; 9008-02-0/deoxyhemoglobin |
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